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Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials
Joint Authors
Philippe, Bourin
Sensebé, Luc
Casteilla, Louis
Valérie, Planat-Bénard
Alessandra, Bura-Rivière
Jérôme, Roncalli
Source
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Abstract EN
Present in numerous tissues, mesenchymal stem cells/multipotent stromal cells (MSCs) can differentiate into different cell types from a mesoderm origin.
Their potential has been extended to pluripotency, by their possibility of differentiating into tissues and cells of nonmesodermic origin.
Through the release of cytokines, growth factors and biologically active molecules, MSCs exert important paracrine effects during tissue repair and inflammation.
Moreover, MSCs have immunosuppressive properties related to non-HLA restricted immunosuppressive capacities.
All these features lead to an increasing range of possible applications of MSCs, from treating immunological diseases to tissue and organ repair, that should be tested in phase I and II clinical trials.
The most widely used MSCs are cultured from bone marrow or adipose tissue.
For clinical trial implementation, BM MSCs and ADSCs should be produced according to Good Manufacturing Practices.
Safety remains the major concern and must be ensured during culture and validated with relevant controls.
We describe some applications of MSCs in clinical trials.
American Psychological Association (APA)
Philippe, Bourin& Sensebé, Luc& Valérie, Planat-Bénard& Jérôme, Roncalli& Alessandra, Bura-Rivière& Casteilla, Louis. 2010. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials. Stem Cells International،Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-476797
Modern Language Association (MLA)
Philippe, Bourin…[et al.]. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials. Stem Cells International No. 2010 (2010), pp.1-8.
https://search.emarefa.net/detail/BIM-476797
American Medical Association (AMA)
Philippe, Bourin& Sensebé, Luc& Valérie, Planat-Bénard& Jérôme, Roncalli& Alessandra, Bura-Rivière& Casteilla, Louis. Culture and Use of Mesenchymal Stromal Cells in Phase I and II Clinical Trials. Stem Cells International. 2010. Vol. 2010, no. 2010, pp.1-8.
https://search.emarefa.net/detail/BIM-476797
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476797