Periodontal Disease : Linking the Primary Inflammation to Bone Loss
Joint Authors
Gigante, Isabella
Di Benedetto, Adriana
Grano, Maria
Colucci, Silvia
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Periodontal disease (PD), or periodontitis, is defined as a bacterially induced disease of the tooth-supporting (periodontal) tissues.
It is characterized by inflammation and bone loss; therefore understanding how they are linked would help to address the most efficacious therapeutic approach.
Bacterial infection is the primary etiology but is not sufficient to induce the disease initiation or progression.
Indeed, bacteria-derived factors stimulate a local inflammatory reaction and activation of the innate immune system.
The innate response involves the recognition of microbial components by host cells, and this event is mediated by toll-like receptors (TLRs) expressed by resident cells and leukocytes.
Activation of these cells leads to the release of proinflammatory cytokines and recruitment of phagocytes and lymphocytes.
Activation of T and B cells initiates the adaptive immunity with Th1 Th2 Th17 Treg response and antibodies production respectively.
In this inflammatory scenario, cytokines involved in bone regulation and maintenance have considerable relevance because tissue destruction is believed to be the consequence of host inflammatory response to the bacterial challenge.
In the present review, we summarize host factors including cell populations, cytokines, and mechanisms involved in the destruction of the supporting tissues of the tooth and discuss treatment perspectives based on this knowledge.
American Psychological Association (APA)
Di Benedetto, Adriana& Gigante, Isabella& Colucci, Silvia& Grano, Maria. 2013. Periodontal Disease : Linking the Primary Inflammation to Bone Loss. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476817
Modern Language Association (MLA)
Di Benedetto, Adriana…[et al.]. Periodontal Disease : Linking the Primary Inflammation to Bone Loss. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-476817
American Medical Association (AMA)
Di Benedetto, Adriana& Gigante, Isabella& Colucci, Silvia& Grano, Maria. Periodontal Disease : Linking the Primary Inflammation to Bone Loss. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-476817
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476817