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Intravenous Thrombolysis in Ischemic Stroke Patients with Intracranial Neoplasms : Two Cases and a Literature Review
Joint Authors
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-05
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Based on exclusion criteria in the landmark NINDS-rtPA trial, current expert consensus guidelines preclude the use of intravenous recombinant tissue plasminogen activator (IV rtPA) in acute ischemic stroke (AIS) patients with intracranial neoplasm.
There are only 3 published cases of administration of IV rtPA to AIS patients with intracranial neoplasms in the literature.
Two of these published cases involved malignant brain parenchymal lesions discovered only after rtPA was inadvertently given, and one of these cases was associated with hemorrhage within the tumor.
In this paper, we report two cases of administration of IV rtPA in AIS patients with intracranial neoplasms observed on neuroimaging prior to IV rtPA administration.
In both cases, the tumor was outside of the brain parenchyma.
The first case was an acoustic schwannoma and the second a falcine meningioma.
Neither case was associated with intratumoral hemorrhage as of at least one week following IV rtPA treatment.
More published cases are definitely warranted, but our experience with these two cases suggests that administration of IV rtPA to AIS patients in the presence of extraparenchymal brain tumors may not necessarily precipitate intra-tumoral bleeding and thereby worsen clinical outcomes.
American Psychological Association (APA)
Neil, William& Ovbiagele, Bruce. 2011. Intravenous Thrombolysis in Ischemic Stroke Patients with Intracranial Neoplasms : Two Cases and a Literature Review. Case Reports in Medicine،Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-476818
Modern Language Association (MLA)
Neil, William& Ovbiagele, Bruce. Intravenous Thrombolysis in Ischemic Stroke Patients with Intracranial Neoplasms : Two Cases and a Literature Review. Case Reports in Medicine No. 2011 (2011), pp.1-3.
https://search.emarefa.net/detail/BIM-476818
American Medical Association (AMA)
Neil, William& Ovbiagele, Bruce. Intravenous Thrombolysis in Ischemic Stroke Patients with Intracranial Neoplasms : Two Cases and a Literature Review. Case Reports in Medicine. 2011. Vol. 2011, no. 2011, pp.1-3.
https://search.emarefa.net/detail/BIM-476818
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476818