Oral-Parenteral Conversion Factor for Morphine in Palliative Cancer Care : A Prospective Randomized Crossover Pilot Study
Joint Authors
Starlander, Jan
Jonsson, Håkan
Axelsson, Bertil
Melin-Johansson, Christina
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-02-15
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Objective.
This pilot study clinically tests whether a conversion factor of 2 to 1 is appropriate when changing from oral to parenteral morphine administration in the treatment of cancer-related nociceptive pain and calculates the size of an adequately powered future study.
Methods.
Eleven outpatients with incurable cancer and well-controlled nociceptive pain were randomly assigned to either intravenous or subcutaneous morphine using half the previous oral 24-hour dose.
Each group crossed over after the first three-day period.
Serum concentrations of morphine and its metabolites were monitored as well as intensity of pain.
Results.
Oral to subcutaneous and oral to intravenous quotas of morphine concentrations were approximately 0.9.
Subcutaneous to intravenous morphine quotas were 1.
Conclusions.
The conversion factor of 2 to 1 seems to be a reasonable average but with an obvious need for individual adjustments.
Concurrent medications and substantially higher doses of morphine could potentially affect the appropriate conversion factor.
An adequately powered study to validate these findings would need at least 121 patients.
American Psychological Association (APA)
Starlander, Jan& Melin-Johansson, Christina& Jonsson, Håkan& Axelsson, Bertil. 2011. Oral-Parenteral Conversion Factor for Morphine in Palliative Cancer Care : A Prospective Randomized Crossover Pilot Study. Pain Research and Treatment،Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-476837
Modern Language Association (MLA)
Starlander, Jan…[et al.]. Oral-Parenteral Conversion Factor for Morphine in Palliative Cancer Care : A Prospective Randomized Crossover Pilot Study. Pain Research and Treatment No. 2011 (2011), pp.1-5.
https://search.emarefa.net/detail/BIM-476837
American Medical Association (AMA)
Starlander, Jan& Melin-Johansson, Christina& Jonsson, Håkan& Axelsson, Bertil. Oral-Parenteral Conversion Factor for Morphine in Palliative Cancer Care : A Prospective Randomized Crossover Pilot Study. Pain Research and Treatment. 2011. Vol. 2011, no. 2011, pp.1-5.
https://search.emarefa.net/detail/BIM-476837
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476837