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The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model : Theoretical and Epidemiological Considerations
Joint Authors
van der Hulst, R. R. W. J.
Ambergen, A. W.
Bast, A.
van den Heuvel, M. G. W.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Statins and other cardiovascular medication possess antioxidant capacity.
It was examined whether chronic use of these medications protects from the development of ischemia-reperfusion (I/R) related complications after DIEP (Deep Inferior Epigastric Perforator Free Flap) surgery.
This paper contains a literature study on the antioxidant working mechanisms of these drugs.
Methods.
Medical information of 134 DIEP patients (173 flaps) was studied from their medical files.
Patient and operative characteristics were registered, as well as I/R related complications.
Results.
Of the group that didnot use statins, 16.3% developed complications versus 30.8% amongst patients that did use these drugs (P= 0.29).
Amongst patients that chronically use other cardiovascular medication, 26.8% developed I/R related complications versus 14.4% of the patients without medication (P= 0.10).
Conclusions.
Chronic use of statins or other cardiovascular medication didnot decrease the occurrence of I/R related complications after DIEP surgery.
Therefore, research should be aimed at evaluating short-term pre-treatment with statins.
American Psychological Association (APA)
van den Heuvel, M. G. W.& Bast, A.& Ambergen, A. W.& van der Hulst, R. R. W. J.. 2012. The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model : Theoretical and Epidemiological Considerations. Journal of Transplantation،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476845
Modern Language Association (MLA)
van den Heuvel, M. G. W.…[et al.]. The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model : Theoretical and Epidemiological Considerations. Journal of Transplantation No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-476845
American Medical Association (AMA)
van den Heuvel, M. G. W.& Bast, A.& Ambergen, A. W.& van der Hulst, R. R. W. J.. The Effect of Statins and Other Cardiovascular Medication on Ischemia-Reperfusion Damage in a Human DIEP Flap Model : Theoretical and Epidemiological Considerations. Journal of Transplantation. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-476845
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476845