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The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells
Joint Authors
Balzan, Rena
Farrugia, Gianluca
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-08-01
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Nonsteroidal anti-inflammatory drugs (NSAIDs) have long been used to treat pain, fever, and inflammation.
However, mounting evidence shows that NSAIDs, such as aspirin, have very promising antineoplastic properties.
The chemopreventive, antiproliferative behaviour of NSAIDs has been associated with both their inactivation of cyclooxygenases (COX) and their ability to induce apoptosis via pathways that are largely COX-independent.
In this review, the various proapoptotic pathways induced by traditional and novel NSAIDs such as phospho-NSAIDs, hydrogen sulfide-releasing NSAIDs and nitric oxide-releasing NSAIDs in mammalian cell lines are discussed, as well as the proapoptotic effects of NSAIDs on budding yeast which retains the hallmarks of mammalian apoptosis.
The significance of these mechanisms in terms of the role of NSAIDs in effective cancer prevention is considered.
American Psychological Association (APA)
Farrugia, Gianluca& Balzan, Rena. 2013. The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells. Oxidative Medicine and Cellular Longevity،Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-476860
Modern Language Association (MLA)
Farrugia, Gianluca& Balzan, Rena. The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells. Oxidative Medicine and Cellular Longevity No. 2013 (2013), pp.1-17.
https://search.emarefa.net/detail/BIM-476860
American Medical Association (AMA)
Farrugia, Gianluca& Balzan, Rena. The Proapoptotic Effect of Traditional and Novel Nonsteroidal Anti-Inflammatory Drugs in Mammalian and Yeast Cells. Oxidative Medicine and Cellular Longevity. 2013. Vol. 2013, no. 2013, pp.1-17.
https://search.emarefa.net/detail/BIM-476860
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476860