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The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence
Joint Authors
Khalaf, Roy A.
Daher, Jalil Y.
Koussa, Joseph
Younes, Samer
Source
Interdisciplinary Perspectives on Infectious Diseases
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-30
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The fungal pathogen Candida albicans is one of the leading causative agents of death in immunocompromised individuals.
It harbors an arsenal of cell wall anchored factors that are implicated in virulence such as filamentation inducing factors, adhesins, lipases, proteases, and superoxide dismutases.
Dse1 is a cell wall protein involved in cell wall metabolism.
The purpose of this study is to characterize the role Dse1 plays in virulence.
Dse1 appears to be an essential gene as no homozygous null mutant was possible.
The heterozygote mutant exhibited increased susceptibility to calcofluor white, a cell wall disrupting agent, with a subsequent reduction in cell wall chitin content, decreased oxidative stress tolerance, a 30% reduction in biofilm formation, and a delay in adhesion that was mirrored by a reduction in virulence in a mouse model of infection.
Dse1 thus appears to be an important protein involved in cell wall integrity and rigidity.
American Psychological Association (APA)
Daher, Jalil Y.& Koussa, Joseph& Younes, Samer& Khalaf, Roy A.. 2011. The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence. Interdisciplinary Perspectives on Infectious Diseases،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476865
Modern Language Association (MLA)
Daher, Jalil Y.…[et al.]. The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence. Interdisciplinary Perspectives on Infectious Diseases No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-476865
American Medical Association (AMA)
Daher, Jalil Y.& Koussa, Joseph& Younes, Samer& Khalaf, Roy A.. The Candida albicans Dse1 Protein Is Essential and Plays a Role in Cell Wall Rigidity, Biofilm Formation, and Virulence. Interdisciplinary Perspectives on Infectious Diseases. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-476865
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476865