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A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease
Joint Authors
Yang, Guang
Wang, Wei
Jin, Yu
Wang, Chunyang
Li, Erguang
Xu, Lanfang
Chen, Xiaoqing
Tan, Ren Xiang
Chen, Xiaoshuang
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-03-10
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Enterovirus 71 (EV71) and coxsackievirus A16 (CVA16) are the causative agents of hand, foot, and mouth disease (HFMD).
During recent epidemics of HFMD in China, medicinal herbals and preparations containing herbal extracts have demonstrated therapeutic efficacy with relative safety profiles.
There have been no microbiological studies to validate their usefulness for HFMD.
We selected 12 commonly used herbs for HFMD from government recommended guidelines as well as published reports and tested for their antiviral activity and anti-inflammatory activity.
A water extract of Houttuynia cordata Thunb.
(HCT) inhibited EV71 infection significantly and was marginally active against CVA16 infection.
The IC50 (concentration to have 50% inhibitory effect) values of HCT against a Fuyang strain and a BrCr strain of EV71 were determined at 8.9 μg/mL and 20.6 μg/mL, respectively.
Mentha haplocalyx Briq.
(MHB) water extract was active against CVA16, with an IC50 value of 70.3 μg/mL.
The extract did not exhibit activity against EV71 infection.
Although the majority of the extracts showed no activity against viral infection, several extracts demonstrated activity in blocking proinflammatory response by viral infection.
This study therefore validates the effectiveness of Chinese herbs for HFMD since some formulations containing the correct combination of the herbs can block viral replication as well as proinflammatory response of HFMD.
American Psychological Association (APA)
Chen, Xiaoqing& Wang, Chunyang& Xu, Lanfang& Chen, Xiaoshuang& Wang, Wei& Yang, Guang…[et al.]. 2013. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476881
Modern Language Association (MLA)
Chen, Xiaoqing…[et al.]. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476881
American Medical Association (AMA)
Chen, Xiaoqing& Wang, Chunyang& Xu, Lanfang& Chen, Xiaoshuang& Wang, Wei& Yang, Guang…[et al.]. A Laboratory Evaluation of Medicinal Herbs Used in China for the Treatment of Hand, Foot, and Mouth Disease. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476881
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476881