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Biliary Adenofibroma of the Liver : Report of a Case and Review of the Literature
Joint Authors
Aprile, Giuseppe
Magro, Gaetano
Gurrera, Alessandra
Leone, Giorgia
Alaggio, Rita
Source
Pathology Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2010-10-28
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
We herein report the clinicopathologic features of a rare case of biliary adenofibroma (BAF) of the liver in a 79-year-old man.
Grossly, tumour presented as a well-circumscribed, 5.5-cm mass with a solid and microcystic appearance.
Histological examination was typical of biliary adenofibroma, showing a proliferation of variable-sized tubulocystic structures embedded in a moderately cellular fibrous stroma.
Immunohistochemistry, revealing immunoreactivity of the epithelial component to cytokeratins 7 and 19, was consistent with a bile duct origin.
Notably, the stromal cells had a myofibroblastic profile, showing a diffuse and strong expression of vimentin and α-smooth muscle actin.
Differential diagnosis with Von Meyenburg complex, biliary adenoma, biliary cistadenoma, congenital biliary cystsy, and hepatic benign cystic mesothelioma is provided.
The occasionally reported expression of p53 in biliary adenofibroma has suggested that this tumour could represent a premalignant lesion.
The absence of both cytological atypia and p53 immunoreactivity in our case confirms that BAF is a benign tumour with an indolent clinical behaviour.
However, a careful histological examination of BAF is mandatory because malignant transformation of the epithelial component has been documented in two cases.
American Psychological Association (APA)
Gurrera, Alessandra& Alaggio, Rita& Leone, Giorgia& Aprile, Giuseppe& Magro, Gaetano. 2010. Biliary Adenofibroma of the Liver : Report of a Case and Review of the Literature. Pathology Research International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-476886
Modern Language Association (MLA)
Gurrera, Alessandra…[et al.]. Biliary Adenofibroma of the Liver : Report of a Case and Review of the Literature. Pathology Research International No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-476886
American Medical Association (AMA)
Gurrera, Alessandra& Alaggio, Rita& Leone, Giorgia& Aprile, Giuseppe& Magro, Gaetano. Biliary Adenofibroma of the Liver : Report of a Case and Review of the Literature. Pathology Research International. 2010. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-476886
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476886