Hu-Lu-Ba-Wan Attenuates Diabetic Nephropathy in Type 2 Diabetic Rats through PKC-αNADPH Oxidase Signaling Pathway
Joint Authors
Chen, Guang
Lu, Fuer
Xu, Lijun
Wang, Kaifu
Zou, Xin
Zhou, Lishan
Huang, Yi
Dong, Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Hu-Lu-Ba-Wan (HLBW) is a Chinese herbal prescription used to treat kidney deficiency.
The aim of this study was to explore the effect and mechanism of HLBW on diabetic nephropathy (DN) in type 2 diabetic rats.
The rat model of DN was established by being fed a high-fat diet and intravenous injection of streptozotocin.
Then, HLBW decoction was administered for 16 weeks.
Blood glucose level, lipid profile, renal function, 24-hour total urinary protein, and albumin content were examined.
Renal morphology and superoxide anion levels were evaluated.
The activity of nicotinamide-adenine dinucleotide phosphate (NADPH) and protein kinase C-alpha (PKC-α) related genes expression in renal tissue were also determined.
Our data demonstrated that HLBW significantly improved hyperglycemia, hyperlipidemia, and proteinuria in diabetic rats compared with those of control group.
HLBW also alleviated glomerular expansion and fibrosis, extracellular matrix accumulation and effacement of the foot processes.
Additionally, HLBW reduced superoxide anion level, NADPH oxidase activity, the protein and mRNA expressions of p47phox, and the protein expression of phosphorylated PKC-α in renal tissue.
These results suggest that HLBW is effective in the treatment of DN in rats.
The underlying mechanism may be related to the attenuation of renal oxidative stress via PKC-α/NADPH oxidase signaling pathway.
American Psychological Association (APA)
Zhou, Lishan& Dong, Hui& Huang, Yi& Xu, Lijun& Zou, Xin& Wang, Kaifu…[et al.]. 2013. Hu-Lu-Ba-Wan Attenuates Diabetic Nephropathy in Type 2 Diabetic Rats through PKC-αNADPH Oxidase Signaling Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476893
Modern Language Association (MLA)
Zhou, Lishan…[et al.]. Hu-Lu-Ba-Wan Attenuates Diabetic Nephropathy in Type 2 Diabetic Rats through PKC-αNADPH Oxidase Signaling Pathway. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-476893
American Medical Association (AMA)
Zhou, Lishan& Dong, Hui& Huang, Yi& Xu, Lijun& Zou, Xin& Wang, Kaifu…[et al.]. Hu-Lu-Ba-Wan Attenuates Diabetic Nephropathy in Type 2 Diabetic Rats through PKC-αNADPH Oxidase Signaling Pathway. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-476893
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476893