Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats
Joint Authors
Lee, Yen-Hsien
Chang, Jung-Jhih
Chien, Chiang-Ting
Chien, Hsiung-Fei
Yang, Ming-Chien
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
We examined the effects of vitamin C in Pluronic F127 on diabetic wound healing.
Full-thickness excision skin wounds were made in normal and diabetic Wistar rats to evaluate the effect of saline, saline plus vitamin C (antioxidant sol), Pluronic F127, or Pluronic F127 plus vitamin C (antioxidant sol-gel).
The rate of wound contraction, the levels of epidermal and dermal maturation, collagen synthesis, and apoptosis production in the wound tissue were determined.
In vitro data showed that after 6 hours of air exposure, the order of the scavenging abilities for HOCl, H2O2, and O2 - was antioxidant sol-gel > antioxidant saline > Pluronic F127 = saline.
After 7 and 14 days of wound injury, the antioxidant sol-gel improved wound healing significantly by accelerated epidermal and dermal maturation, an increase in collagen content, and a decrease in apoptosis formation.
However, the wounds of all treatments healed mostly at 3 weeks.
Vitamin C in Pluronic F127 hastened cutaneous wound healing by its antioxidant and antiapoptotic mechanisms through a good drug delivery system.
This study showed that Pluronic F127 plus vitamin C could potentially be employed as a novel wound-healing enhancer.
American Psychological Association (APA)
Lee, Yen-Hsien& Chang, Jung-Jhih& Chien, Chiang-Ting& Yang, Ming-Chien& Chien, Hsiung-Fei. 2012. Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476899
Modern Language Association (MLA)
Lee, Yen-Hsien…[et al.]. Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Experimental Diabetes Research No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-476899
American Medical Association (AMA)
Lee, Yen-Hsien& Chang, Jung-Jhih& Chien, Chiang-Ting& Yang, Ming-Chien& Chien, Hsiung-Fei. Antioxidant Sol-Gel Improves Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-476899
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476899