An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease
Joint Authors
Huang, Xiaoyan
Yang, Xi
Jiang, Xin
Zhou, Jiangqing
Ye, Huadan
Lian, Jiangfang
Peng, Ping
Ba, Yanna
Lu, Yae
Duan, Shiwei
Chen, Xiaoliang
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-26
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The goal of our study is to test the association of IL6R rs7529229 polymorphism with CHD through a case-control study in Han Chinese population and a meta-analysis.
Our result showed there is a lack of association between IL6R rs7529229 polymorphism and CHD on both genotype and allele levels in Han Chinese (P>0.05).
However, a meta-analysis among 11678 cases and 12861 controls showed that rs7529229-C allele was significantly associated with a decreased risk of CHD, especially in Europeans (P<0.0001, odds ratio = 0.93, 95% confidential interval = 0.89–0.96).
Since there is significant difference among different populations, further studies are warranted to test the contribution of rs7529229 to CHD in other ethnic populations.
American Psychological Association (APA)
Zhou, Jiangqing& Chen, Xiaoliang& Ye, Huadan& Peng, Ping& Ba, Yanna& Yang, Xi…[et al.]. 2014. An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-476904
Modern Language Association (MLA)
Zhou, Jiangqing…[et al.]. An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-476904
American Medical Association (AMA)
Zhou, Jiangqing& Chen, Xiaoliang& Ye, Huadan& Peng, Ping& Ba, Yanna& Yang, Xi…[et al.]. An Association Study between Genetic Polymorphism in the Interleukin-6 Receptor Gene and Coronary Heart Disease. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-476904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476904