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Roles of Renal Proximal Tubule Transport in AcidBase Balance and Blood Pressure Regulation
Joint Authors
Satoh, Nobuhiko
Horita, Shoko
Shirai, Ayumi
Nakamura, Motonobu
Yamazaki, Osamu
Seki, George
Suzuki, Masashi
Yamada, Hideomi
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-05-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Sodium-coupled bicarbonate absorption from renal proximal tubules (PTs) plays a pivotal role in the maintenance of systemic acid/base balance.
Indeed, mutations in the Na+-HCO3- cotransporter NBCe1, which mediates a majority of bicarbonate exit from PTs, cause severe proximal renal tubular acidosis associated with ocular and other extrarenal abnormalities.
Sodium transport in PTs also plays an important role in the regulation of blood pressure.
For example, PT transport stimulation by insulin may be involved in the pathogenesis of hypertension associated with insulin resistance.
Type 1 angiotensin (Ang) II receptors in PT are critical for blood pressure homeostasis.
Paradoxically, the effects of Ang II on PT transport are known to be biphasic.
Unlike in other species, however, Ang II is recently shown to dose-dependently stimulate human PT transport via nitric oxide/cGMP/ERK pathway, which may represent a novel therapeutic target in human hypertension.
In this paper, we will review the physiological and pathophysiological roles of PT transport.
American Psychological Association (APA)
Nakamura, Motonobu& Shirai, Ayumi& Yamazaki, Osamu& Satoh, Nobuhiko& Suzuki, Masashi& Horita, Shoko…[et al.]. 2014. Roles of Renal Proximal Tubule Transport in AcidBase Balance and Blood Pressure Regulation. BioMed Research International،Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476912
Modern Language Association (MLA)
Nakamura, Motonobu…[et al.]. Roles of Renal Proximal Tubule Transport in AcidBase Balance and Blood Pressure Regulation. BioMed Research International No. 2014 (2014), pp.1-7.
https://search.emarefa.net/detail/BIM-476912
American Medical Association (AMA)
Nakamura, Motonobu& Shirai, Ayumi& Yamazaki, Osamu& Satoh, Nobuhiko& Suzuki, Masashi& Horita, Shoko…[et al.]. Roles of Renal Proximal Tubule Transport in AcidBase Balance and Blood Pressure Regulation. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-7.
https://search.emarefa.net/detail/BIM-476912
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476912