PPAR Medicines and Human Disease : The ABCs of It All
Joint Authors
Nicol, Christopher J. B.
Apostoli, Anthony J.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-07
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
ATP-dependent binding cassette (ABC) transporters are a family of transmembrane proteins that pump a variety of hydrophobic compounds across cellular and subcellular barriers and are implicated in human diseases such as cancer and atherosclerosis.
Inhibition of ABC transporter activity showed promise in early preclinical studies; however, the outcomes in clinical trials with these agents have not been as encouraging.
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that regulate genes involved in fat and glucose metabolism, and inflammation.
Activation of PPAR signaling is also reported to regulate ABC gene expression.
This suggests the potential of PPAR medicines as a novel means of controlling ABC transporter activity at the transcriptional level.
This paper summarizes the advances made in understanding how PPAR medicines affect ABC transporters, and the potential implications for impacting on human diseases, in particular with respect to cancer and atherosclerosis.
American Psychological Association (APA)
Apostoli, Anthony J.& Nicol, Christopher J. B.. 2012. PPAR Medicines and Human Disease : The ABCs of It All. PPAR Research،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-476926
Modern Language Association (MLA)
Apostoli, Anthony J.& Nicol, Christopher J. B.. PPAR Medicines and Human Disease : The ABCs of It All. PPAR Research No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-476926
American Medical Association (AMA)
Apostoli, Anthony J.& Nicol, Christopher J. B.. PPAR Medicines and Human Disease : The ABCs of It All. PPAR Research. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-476926
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476926