Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3
Joint Authors
Shuvayeva, Galyna
Morani, Federica
Igumentseva, Natalia
Isidoro, Ciro
Bobak, Yaroslav
Titone, Rossella
Stasyk, Oleh
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-01
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Autophagy is a process of cytosol-to-lysosome vesicle trafficking of cellular constituents for degradation and recycling of their building blocks.
Autophagy becomes very important for cell viability under different stress conditions, in particular under amino acid limitation.
In this report we demonstrate that single amino acid arginine deprivation triggers profound prosurvival autophagic response in cultured human ovarian cancer SKOV3 cells.
In fact, a significant drop in viability of arginine-starved SKOV3 cells was observed when autophagy was inhibited by either coadministration of chloroquine or transcriptional silencing of the essential autophagy protein BECLIN 1.
Enzymatic arginine deprivation is a novel anticancer therapy undergoing clinical trials.
This therapy is considered nontoxic and selective, as it allows controlling the growth of malignant tumours deficient in arginine biosynthesis.
We propose that arginine deprivation-based combinational treatments that include autophagy inhibitors (e.g., chloroquine) may produce a stronger anticancer effect as a second line therapy for a subset of chemoresistant ovarian cancers.
American Psychological Association (APA)
Shuvayeva, Galyna& Bobak, Yaroslav& Igumentseva, Natalia& Titone, Rossella& Morani, Federica& Stasyk, Oleh…[et al.]. 2014. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3. BioMed Research International،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-476936
Modern Language Association (MLA)
Shuvayeva, Galyna…[et al.]. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3. BioMed Research International No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-476936
American Medical Association (AMA)
Shuvayeva, Galyna& Bobak, Yaroslav& Igumentseva, Natalia& Titone, Rossella& Morani, Federica& Stasyk, Oleh…[et al.]. Single Amino Acid Arginine Deprivation Triggers Prosurvival Autophagic Response in Ovarian Carcinoma SKOV3. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-476936
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476936