Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats
Joint Authors
Kumar, Vikas
Chatterjee, Shyam Sunder
Husain, Gulam Mohammed
Singh, Paras Nath
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-04-12
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Pharmacology
Abstract EN
Hypericum perforatum is known to have diverse medicinal uses for centuries.
The antidepressant activity of Hypericum perforatum is widely accepted and proved in both animal and clinical studies.
Present study was undertaken to investigate the effect of Hypericum perforatum in a battery of animal models for metabolic disorder.
Hypericum is tested for hypolipidemic activity in normal rats, antiobesity activity in high-fat-diet induced obese rats, and fructose-fed rats.
Hypericum was orally administered as suspension in 0.3% carboxymethyl cellulose at the doses of 100 and 200 mg/kg body weight for 15 consecutive days.
Hypericum significantly lowered total cholesterol and low-density cholesterol in normal rats.
Hypericum significantly inhibited weight gain in high-fat-fed rats.
In fructose-fed rats, Hypericum normalised the dyslipidemia induced by fructose feeding and improved the insulin sensitivity.
Taken together, Hypericum could be the antidepressant therapy of choice for patients suffering from comorbid diabetes and obesity.
American Psychological Association (APA)
Husain, Gulam Mohammed& Chatterjee, Shyam Sunder& Singh, Paras Nath& Kumar, Vikas. 2011. Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats. ISRN Pharmacology،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-476953
Modern Language Association (MLA)
Husain, Gulam Mohammed…[et al.]. Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats. ISRN Pharmacology No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-476953
American Medical Association (AMA)
Husain, Gulam Mohammed& Chatterjee, Shyam Sunder& Singh, Paras Nath& Kumar, Vikas. Hypolipidemic and Antiobesity-Like Activity of Standardised Extract of Hypericum perforatum L. in Rats. ISRN Pharmacology. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-476953
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476953