What Are the bona fide GSK3 Substrates?
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-18
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Nearly 100 proteins are proposed to be substrates for GSK3, suggesting that this enzyme is a fundamental regulator of almost every process in the cell, in every tissue in the body.
However, it is not certain how many of these proposed substrates are regulated by GSK3 in vivo.
Clearly, the identification of the physiological functions of GSK3 will be greatly aided by the identification of its bona fide substrates, and the development of GSK3 as a therapeutic target will be highly influenced by this range of actions, hence the need to accurately establish true GSK3 substrates in cells.
In this paper the evidence that proposed GSK3 substrates are likely to be physiological targets is assessed, highlighting the key cellular processes that could be modulated by GSK3 activity and inhibition.
American Psychological Association (APA)
Sutherland, Calum. 2011. What Are the bona fide GSK3 Substrates?. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-476976
Modern Language Association (MLA)
Sutherland, Calum. What Are the bona fide GSK3 Substrates?. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-23.
https://search.emarefa.net/detail/BIM-476976
American Medical Association (AMA)
Sutherland, Calum. What Are the bona fide GSK3 Substrates?. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-23.
https://search.emarefa.net/detail/BIM-476976
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-476976