Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936
Joint Authors
Davies, Gail
Liewald, David C.
Tenesa, Albert
Deary, Ian J.
Hamilton, Gillian
Porteous, David
Starr, John M.
Harris, Sarah E.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-12
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Alzheimer's disease patients have deficits in specific cognitive domains, and susceptibility genes for this disease may influence human cognition in nondemented individuals.
To evaluate the role of Alzheimer's disease-linked genetic variation on cognition and normal cognitive ageing, we investigated two Scottish cohorts for which assessments in major cognitive domains are available: the Lothian Birth Cohort of 1921 and the Lothian Birth Cohort of 1936, consisting of 505 and 998 individuals, respectively.
158 SNPs from eleven genes were evaluated.
Single SNP analyses did not reveal any statistical association after correction for multiple testing.
One haplotype from TRAPPC6A was associated with nonverbal reasoning in both cohorts and combined data sets.
This haplotype explains a small proportion of the phenotypic variability (1.8%).
These findings warrant further investigation as biological modifiers of cognitive ageing.
American Psychological Association (APA)
Hamilton, Gillian& Harris, Sarah E.& Davies, Gail& Liewald, David C.& Tenesa, Albert& Starr, John M.…[et al.]. 2011. Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936. International Journal of Alzheimer's Disease،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-477009
Modern Language Association (MLA)
Hamilton, Gillian…[et al.]. Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936. International Journal of Alzheimer's Disease No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-477009
American Medical Association (AMA)
Hamilton, Gillian& Harris, Sarah E.& Davies, Gail& Liewald, David C.& Tenesa, Albert& Starr, John M.…[et al.]. Alzheimer's Disease Genes Are Associated with Measures of Cognitive Ageing in the Lothian Birth Cohorts of 1921 and 1936. International Journal of Alzheimer's Disease. 2011. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-477009
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477009
