Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug : Promising Insights in the Treatment of Chronic Inflammatory Diseases
Joint Authors
Minetti, Alejandra
Gumilar, Fernanda
Toso, Ricardo
Boeris, Mónica
Agotegaray, Mariela
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-19
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Analgesic and ulcerogenic properties have been studied for the copper(II) coordination complex of the nonsteroidal anti-inflammatory drug Fenoprofen and imidazole [Cu(fen)2(im)2] (Cu: copper(II) ion; fen: fenoprofenate anion from Fenoprofen, im: imidazole).
A therapeutic dose of 28 mg/kg was tested for [Cu(fen)2(im)2] and 21 mg/kg was employed for Fenoprofen calcium, administered by oral gavage in female mice to compare the therapeutic properties of the new entity.
The acetic acid induced writhing test was employed to study visceral pain.
The percentage of inhibition in writhing and stretching was 78.9% and 46.2% for the [Cu(fen)2(im)2] and Fenoprofen calcium, respectively.
This result indicates that the complex could be more effective in diminishing visceral pain.
The formalin test was evaluated to study the impact of the drugs over nociceptive and inflammatory pain.
The complex is a more potent analgesic on inflammatory pain than the parent drug.
Ulcerogenic effects were evaluated using a model of gastric lesions induced by hypothermic-restraint stress.
Fenoprofen calcium salt caused an ulcer index of about 79 mm2 while the one caused by [Cu(fen)2(im)2] was 22 mm2.
The complex diminished the development of gastric mucosal ulcers in comparison to the uncomplexed drug.
Possible mechanisms of action related to both therapeutic properties have been discussed.
American Psychological Association (APA)
Agotegaray, Mariela& Gumilar, Fernanda& Boeris, Mónica& Toso, Ricardo& Minetti, Alejandra. 2014. Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug : Promising Insights in the Treatment of Chronic Inflammatory Diseases. BioMed Research International،Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477010
Modern Language Association (MLA)
Agotegaray, Mariela…[et al.]. Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug : Promising Insights in the Treatment of Chronic Inflammatory Diseases. BioMed Research International No. 2014 (2014), pp.1-9.
https://search.emarefa.net/detail/BIM-477010
American Medical Association (AMA)
Agotegaray, Mariela& Gumilar, Fernanda& Boeris, Mónica& Toso, Ricardo& Minetti, Alejandra. Enhanced Analgesic Properties and Reduced Ulcerogenic Effect of a Mononuclear Copper(II) Complex with Fenoprofen in Comparison to the Parent Drug : Promising Insights in the Treatment of Chronic Inflammatory Diseases. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-9.
https://search.emarefa.net/detail/BIM-477010
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477010