Molecular Mechanisms of Neonatal Brain Injury
Joint Authors
Rousset, Catherine I.
Vontell, Regina
Miyakuni, Yasuka
Fleiss, Bobbi
Baburamani, Ana A.
Kichev, Anton
Hagberg, Henrik
Thornton, Claire
Gressens, Pierre
Source
Neurology Research International
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-26
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Fetal/neonatal brain injury is an important cause of neurological disability.
Hypoxia-ischemia and excitotoxicity are considered important insults, and, in spite of their acute nature, brain injury develops over a protracted time period during the primary, secondary, and tertiary phases.
The concept that most of the injury develops with a delay after the insult makes it possible to provide effective neuroprotective treatment after the insult.
Indeed, hypothermia applied within 6 hours after birth in neonatal encephalopathy reduces neurological disability in clinical trials.
In order to develop the next generation of treatment, we need to know more about the pathophysiological mechanism during the secondary and tertiary phases of injury.
We review some of the critical molecular events related to mitochondrial dysfunction and apoptosis during the secondary phase and report some recent evidence that intervention may be feasible also days-weeks after the insult.
American Psychological Association (APA)
Thornton, Claire& Rousset, Catherine I.& Kichev, Anton& Miyakuni, Yasuka& Vontell, Regina& Baburamani, Ana A.…[et al.]. 2012. Molecular Mechanisms of Neonatal Brain Injury. Neurology Research International،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-477045
Modern Language Association (MLA)
Thornton, Claire…[et al.]. Molecular Mechanisms of Neonatal Brain Injury. Neurology Research International No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-477045
American Medical Association (AMA)
Thornton, Claire& Rousset, Catherine I.& Kichev, Anton& Miyakuni, Yasuka& Vontell, Regina& Baburamani, Ana A.…[et al.]. Molecular Mechanisms of Neonatal Brain Injury. Neurology Research International. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-477045
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477045