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Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 andor mTOR Pathways in Human Multiple Myeloma Cells
Joint Authors
Jeong, Soo-Jin
Jung, Ji Hoon
Sohn, Eun Jung
Kim, Ji-Hyun
Jang, Jinsil
Kim, Jin Hyoung
Lee, Hyo-Jung
Kim, Sung-Hoon
Kim, Sun-Hee
Kwon, Hee-Young
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-05-13
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Background.
Combination cancer therapy is one of the attractive approaches to overcome drug resistance of cancer cells.
In the present study, we investigated the synergistic effect of decursin from Angelica gigas and doxorubicin on the induction of apoptosis in three human multiple myeloma cells.
Methodology/Principal Findings.
Combined treatment of decursin and doxorubicin significantly exerted significant cytotoxicity compared to doxorubicin or decursin in U266, RPMI8226, and MM.1S cells.
Furthermore, the combination treatment enhanced the activation of caspase-9 and -3, the cleavage of PARP, and the sub G1 population compared to either drug alone in three multiple myeloma cells.
In addition, the combined treatment downregulated the phosphorylation of mTOR and its downstream S6K1 and activated the phosphorylation of ERK in three multiple myeloma cells.
Furthermore, the combined treatment reduced mitochondrial membrane potential, suppressed the phosphorylation of JAK2, STAT3, and Src, activated SHP-2, and attenuated the expression of cyclind-D1 and survivin in U266 cells.
Conversely, tyrosine phosphatase inhibitor pervanadate reversed STAT3 inactivation and also PARP cleavage and caspase-3 activation induced by combined treatment of doxorubicin and decursin in U266 cells.
Conclusions/Significance.
Overall, the combination treatment of decursin and doxorubicin can enhance apoptotic activity via mTOR and/or STAT3 signaling pathway in multiple myeloma cells.
American Psychological Association (APA)
Jang, Jinsil& Jeong, Soo-Jin& Kwon, Hee-Young& Jung, Ji Hoon& Sohn, Eun Jung& Lee, Hyo-Jung…[et al.]. 2013. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 andor mTOR Pathways in Human Multiple Myeloma Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-477046
Modern Language Association (MLA)
Jang, Jinsil…[et al.]. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 andor mTOR Pathways in Human Multiple Myeloma Cells. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-13.
https://search.emarefa.net/detail/BIM-477046
American Medical Association (AMA)
Jang, Jinsil& Jeong, Soo-Jin& Kwon, Hee-Young& Jung, Ji Hoon& Sohn, Eun Jung& Lee, Hyo-Jung…[et al.]. Decursin and Doxorubicin Are in Synergy for the Induction of Apoptosis via STAT3 andor mTOR Pathways in Human Multiple Myeloma Cells. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-13.
https://search.emarefa.net/detail/BIM-477046
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477046