Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients : Alteration of the PPARγ-Dependent Pathways
Joint Authors
Vigouroux, Corinne
Caron, Martine
Capeau, Jacqueline
Bastard, Jean-Philippe
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2008-12-30
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Lipodystrophy and metabolic alterations are major complications of antiretroviral therapy in HIV-infected patients.
In vitro studies using cultured murine and human adipocytes revealed that some protease inhibitors (PIs) and nucleoside reverse transcriptase inhibitors (NRTIs) were implicated to a different extent in adipose cell dysfunction and that a chronic incubation with some PIs decreased mRNA and protein expression of PPARγ.
Defective lamin A maturation linked to PI inhibitory activity could impede the nuclear translocation of SREBP1c, therefore, reducing PPARγ expression.
Adipose cell function was partially restored by the PPARγ agonists, thiazolidinediones.
Adverse effects of PIs and NRTIs have also been reported in macrophages, a cell type that coexists with, and modulates, adipocyte function in fat tissue.
In HIV-infected patients under ART, a decreased expression of PPARγ and of PPARγ-related genes was observed in adipose tissue, these anomalies being more severe in patients with ART-induced lipoatrophy.
Altered PPARγ expression was reversed in patients stopping PIs.
Treatment of patients with agonists of PPARγ could improve, at least partially, the subcutaneous lipoatrophy.
These data indicate that decreased PPARγ expression and PPARγ-related function, resulting from ART-induced adipose tissue toxicity, play a central role in HIV-related lipoatrophy and metabolic consequences.
American Psychological Association (APA)
Caron, Martine& Vigouroux, Corinne& Bastard, Jean-Philippe& Capeau, Jacqueline. 2008. Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients : Alteration of the PPARγ-Dependent Pathways. PPAR Research،Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-477111
Modern Language Association (MLA)
Caron, Martine…[et al.]. Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients : Alteration of the PPARγ-Dependent Pathways. PPAR Research No. 2009 (2009), pp.1-8.
https://search.emarefa.net/detail/BIM-477111
American Medical Association (AMA)
Caron, Martine& Vigouroux, Corinne& Bastard, Jean-Philippe& Capeau, Jacqueline. Antiretroviral-Related Adipocyte Dysfunction and Lipodystrophy in HIV-Infected Patients : Alteration of the PPARγ-Dependent Pathways. PPAR Research. 2008. Vol. 2009, no. 2009, pp.1-8.
https://search.emarefa.net/detail/BIM-477111
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477111