HIV-Associated Hodgkin's Lymphoma : Prognosis and Therapy in the Era of cART
Joint Authors
Abramson, Jeremy S.
Jacobson, Caron A.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) are at increased risk for developing Hodgkin's lymphoma (HL), a risk that has not decreased despite the success of combination antiretroviral therapy (cART) in the modern era.
HIV-associated HL (HIV-HL) differs from HL in non-HIV-infected patients in that it is nearly always associated with Epstein-Barr virus (EBV) and more often presents with high-risk features of advanced disease, systemic “B” symptoms, and extranodal involvement.
Before the introduction of cART, patients with HIV-HL had lower response rates and worse outcomes than non-HIV-infected HL patients treated with conventional chemotherapy.
The introduction of cART, however, has allowed for the delivery of full-dose and dose-intensive chemotherapy regimens with improved outcomes that approach those seen in non-HIV infected patients.
Despite these significant advances, HIV-HL patients remain at increased risk for treatment-related toxicities and drug-drug interactions which require careful attention and supportive care to insure the safe administration of therapy.
This paper will address the modern diagnosis, risk stratification, and therapy of HIV-associated HL.
American Psychological Association (APA)
Jacobson, Caron A.& Abramson, Jeremy S.. 2012. HIV-Associated Hodgkin's Lymphoma : Prognosis and Therapy in the Era of cART. Advances in Hematology،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-477125
Modern Language Association (MLA)
Jacobson, Caron A.& Abramson, Jeremy S.. HIV-Associated Hodgkin's Lymphoma : Prognosis and Therapy in the Era of cART. Advances in Hematology No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-477125
American Medical Association (AMA)
Jacobson, Caron A.& Abramson, Jeremy S.. HIV-Associated Hodgkin's Lymphoma : Prognosis and Therapy in the Era of cART. Advances in Hematology. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-477125
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477125