Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond
Author
Source
Journal of Signal Transduction
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
The protein tyrosine kinase Syk plays a critical role in FcεRI signaling in mast cells.
Binding of Syk to phosphorylated immunoreceptor tyrosine-based activation motifs (p-ITAM) of the receptor subunits results in conformational changes and tyrosine phosphorylation at multiple sites that leads to activation of Syk.
The phosphorylated tyrosines throughout the molecule play an important role in the regulation of Syk-mediated signaling.
Reconstitution of receptor-mediated signaling in Syk-/- cells by wild-type Syk or mutants which have substitution of these tyrosines with phenylalanine together with in vitro assays has been useful strategies to understand the regulation and function of Syk.
American Psychological Association (APA)
de Castro, Rodrigo Orlandini. 2011. Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond. Journal of Signal Transduction،Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-477130
Modern Language Association (MLA)
de Castro, Rodrigo Orlandini. Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond. Journal of Signal Transduction No. 2011 (2011), pp.1-9.
https://search.emarefa.net/detail/BIM-477130
American Medical Association (AMA)
de Castro, Rodrigo Orlandini. Regulation and Function of Syk Tyrosine Kinase in Mast Cell Signaling and Beyond. Journal of Signal Transduction. 2011. Vol. 2011, no. 2011, pp.1-9.
https://search.emarefa.net/detail/BIM-477130
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477130