Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS : A Pilot Study
Joint Authors
Kim, Sung K.
Ul Haq, Ihtsham
Jacobson, Charles E.
Resnick, Andrew S.
Okun, Michael S.
Fernandez, Hubert H.
Dai, Yunfeng
Wu, Samuel S.
Malaty, Irene A.
Foote, Kelly D.
Hwynn, Nelson
Oyama, Genko
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-4, 4 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-19
Country of Publication
Egypt
No. of Pages
4
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
Parkinson’s disease (PD) management has traditionally focused largely on motor symptoms.
Deep brain stimulation (DBS) of the subthalamic nucleus (STN) and globus pallidus internus (GPi) are effective treatments for motor symptoms.
Nonmotor symptoms (NMSs) may also profoundly affect the quality of life.
The purpose of this pilot study was to evaluate NMS changes pre- and post-DBS utilizing two recently developed questionnaires.
Methods.
NMS-Q (questionnaire) and NMS-S (scale) were administered to PD patients before/after unilateral DBS (STN/GPi targets).
Results.
Ten PD patients (9 STN implants, 1 GPi implant) were included.
The three most frequent NMS symptoms identified utilizing NMS-Q in pre-surgical patients were gastrointestinal (100%), sleep (100%), and urinary (90%).
NMS sleep subscore significantly decreased (−1.6 points ± 1.8, P=0.03).
The three most frequent NMS symptoms identified in pre-surgical patients using NMS-S were gastrointestinal (90%), mood (80%), and cardiovascular (80%).
The largest mean decrease of NMS scores was seen in miscellaneous symptoms (pain, anosmia, weight change, and sweating) (−7 points ± 8.7), and cardiovascular/falls (−1.9, P=0.02).
Conclusion.
Non-motor symptoms improved on two separate questionnaires following unilateral DBS for PD.
Future studies are needed to confirm these findings and determine their clinical significance as well as to examine the strengths/weaknesses of each questionnaire/scale.
American Psychological Association (APA)
Hwynn, Nelson& Ul Haq, Ihtsham& Malaty, Irene A.& Resnick, Andrew S.& Dai, Yunfeng& Foote, Kelly D.…[et al.]. 2011. Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS : A Pilot Study. Oxidative Medicine and Cellular Longevity،Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-477146
Modern Language Association (MLA)
Hwynn, Nelson…[et al.]. Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS : A Pilot Study. Oxidative Medicine and Cellular Longevity No. 2011 (2011), pp.1-4.
https://search.emarefa.net/detail/BIM-477146
American Medical Association (AMA)
Hwynn, Nelson& Ul Haq, Ihtsham& Malaty, Irene A.& Resnick, Andrew S.& Dai, Yunfeng& Foote, Kelly D.…[et al.]. Effect of Deep Brain Stimulation on Parkinson's Nonmotor Symptoms following Unilateral DBS : A Pilot Study. Oxidative Medicine and Cellular Longevity. 2011. Vol. 2011, no. 2011, pp.1-4.
https://search.emarefa.net/detail/BIM-477146
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477146