The Effect of Amifostine on Submandibular Gland Histology after Radiation
Joint Authors
Tang, Mei
Ha, Patrick K.
Sciubba, James J.
Palermo, Robert A.
Levine, Marshall A.
Zinreich, Eva S.
Califano, Joseph A.
Bishop, Justin A.
Fakhry, Carole
Saunders, John R.
Blanco, Ray G.
Junn, Jacqueline C.
Source
International Journal of Otolaryngology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-15
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
The purpose of this study was to assess the effects of amifostine on submandibular gland histology in patients receiving chemoradiation therapy.
Methods.
We conducted a retrospective submandibular gland histologic slide review of HNSCC patients receiving chemoradiation for head and neck squamous cell carcinoma with three different levels of amifostine exposure.
We used six scoring parameters: fatty replacement, lobular architecture degeneration, interstitial fibrosis, ductal degeneration, acinar degeneration, and inflammatory component presence.
Results.
Differences in gender, tumor stage, amifostine dose, age, number of days after neck dissection, and smoking history (pack years) exposure were not significant between the three groups, although there was a difference between groups in the primary subsite (P=0.006).
The nonparametric Cuzick's test for histologic parameters with varied amifostine treatment showed no significance among the three groups.
Conclusions.
Although patients did not receive a full dose of amifostine due to side effects, varying doses of amifostine had no apparent evident cytoprotective effects in three groups of cancer patients treated with primary chemoradiation.
American Psychological Association (APA)
Junn, Jacqueline C.& Sciubba, James J.& Bishop, Justin A.& Zinreich, Eva S.& Tang, Mei& Levine, Marshall A.…[et al.]. 2012. The Effect of Amifostine on Submandibular Gland Histology after Radiation. International Journal of Otolaryngology،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477212
Modern Language Association (MLA)
Junn, Jacqueline C.…[et al.]. The Effect of Amifostine on Submandibular Gland Histology after Radiation. International Journal of Otolaryngology No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-477212
American Medical Association (AMA)
Junn, Jacqueline C.& Sciubba, James J.& Bishop, Justin A.& Zinreich, Eva S.& Tang, Mei& Levine, Marshall A.…[et al.]. The Effect of Amifostine on Submandibular Gland Histology after Radiation. International Journal of Otolaryngology. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477212