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Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation
Joint Authors
Kim, Jeungshin
Kim, Hyunseong
Kim, Sun Kwang
Hwang, Deok-Sang
Lee, Sanghoon
Ko, Eunjung
Bae, Hyunsu
Nam, Sangsoo
Baek, Yonghyeon
Min, Byung-Il
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Clinical evidence indicates that electroacupuncture (EA) is effective for allergic disorder.
Recent animal studies have shown that EA treatment reduces levels of IgE and Th2 cytokines in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH).
The hypothalamus, a brain center of the neural-immune system, is known to be activated by EA stimulation.
This study was performed to identify and characterize the differentially expressed genes in the hypothalamus of DNP-KLH immunized mice that were stimulated with EA or only restrained.
To this aim, we conducted a microarray analysis to evaluate the global gene expression profiles, using the hypothalamic RNA samples taken from three groups of mice: (i) normal control group (no treatments); (ii) IMH group (DNP-KLH immunization + restraint); and (iii) IMEA group (immunization + EA stimulation).
The microarray analysis revealed that total 39 genes were altered in their expression levels by EA treatment.
Ten genes, including T-cell receptor alpha variable region family 13 subfamily 1 (Tcra-V13.1), heat shock protein 1B (Hspa1b) and 2′–5′ oligoadenylate synthetase 1F (Oas1f), were up-regulated in the IMEA group when compared with the IMH group.
In contrast, 29 genes, including decay accelerating factor 2 (Daf2), NAD(P)H dehydrogenase, quinone 1 (Nqo1) and programmed cell death 1 ligand 2 (Pdcd1lg2) were down-regulated in the IMEA group as compared with the IMH group.
These results suggest that EA treatment can modulate immune response in DNP-KLH immunized mice by regulating expression levels of genes that are associated with innate immune, cellular defense and/or other kinds of immune system in the hypothalamus.
American Psychological Association (APA)
Kim, Sun Kwang& Kim, Jeungshin& Ko, Eunjung& Kim, Hyunseong& Hwang, Deok-Sang& Lee, Sanghoon…[et al.]. 2011. Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine،Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477241
Modern Language Association (MLA)
Kim, Sun Kwang…[et al.]. Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine No. 2011 (2011), pp.1-8.
https://search.emarefa.net/detail/BIM-477241
American Medical Association (AMA)
Kim, Sun Kwang& Kim, Jeungshin& Ko, Eunjung& Kim, Hyunseong& Hwang, Deok-Sang& Lee, Sanghoon…[et al.]. Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2011, no. 2011, pp.1-8.
https://search.emarefa.net/detail/BIM-477241
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477241