Interplay between HIV-1 and Host Genetic Variation : A Snapshot into Its Impact on AIDS and Therapy Response
Joint Authors
Luo, M.
Shadabi, Elnaz
Sampathkumar, Raghavan
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-16
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
As of February 2012, 50 circulating recombinant forms (CRFs) have been reported for HIV-1 while one CRF for HIV-2.
Also according to HIV sequence compendium 2011, the HIV sequence database is replete with 414,398 sequences.
The fact that there are CRFs, which are an amalgamation of sequences derived from six or more subtypes (CRF27_cpx (cpx refers to complex) is a mosaic with sequences from 6 different subtypes besides an unclassified fragment), serves as a testimony to the continual divergent evolution of the virus with its approximate 1% per year rate of evolution, and this phenomena per se poses tremendous challenge for vaccine development against HIV/AIDS, a devastating disease that has killed 1.8 million patients in 2010.
Here, we explore the interaction between HIV-1 and host genetic variation in the context of HIV/AIDS and antiretroviral therapy response.
American Psychological Association (APA)
Sampathkumar, Raghavan& Shadabi, Elnaz& Luo, M.. 2012. Interplay between HIV-1 and Host Genetic Variation : A Snapshot into Its Impact on AIDS and Therapy Response. Advances in Virology،Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-477266
Modern Language Association (MLA)
Sampathkumar, Raghavan…[et al.]. Interplay between HIV-1 and Host Genetic Variation : A Snapshot into Its Impact on AIDS and Therapy Response. Advances in Virology No. 2012 (2012), pp.1-16.
https://search.emarefa.net/detail/BIM-477266
American Medical Association (AMA)
Sampathkumar, Raghavan& Shadabi, Elnaz& Luo, M.. Interplay between HIV-1 and Host Genetic Variation : A Snapshot into Its Impact on AIDS and Therapy Response. Advances in Virology. 2012. Vol. 2012, no. 2012, pp.1-16.
https://search.emarefa.net/detail/BIM-477266
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477266