Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells
Joint Authors
Maria-Engler, Silvya Stuchi
Massaro, Renato Ramos
Campa, Ana
Knebel, Franciele Hinterholz
Albuquerque, Renata Chaves
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-25
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Evidence sustains a role for the acute-phase protein serum amyloid A (SAA) in carcinogenesis and metastasis, and the protein has been suggested as a marker for tumor progression.
Nevertheless, the demonstration of a direct activity of SAA on tumor cells is still incipient.
We have investigated the effect of human recombinant SAA (rSAA) on two human glioma cell lines, A172 and T98G.
rSAA stimulated the [3H]-thymidine incorporation of both lines, but had dual effects on migration and invasiveness which varied according to the cell line.
In T98G, the rSAA increased migration and invasion behaviors whereas in A172 it decreased these behaviors.
These findings agree with the effect triggered by rSAA on matrix metalloproteinases (MMPs) activities measured in a gelatinolytic assay.
rSAA inhibited activity of both MMPs in A172 cells while increasing them in T98G cells.
rSAA also affected the production of compounds present in the tumor microenvironment that orchestrate tumor progression, such as IL-8, the production of reactive oxygen species (ROS) and nitric oxide (NO).
We also observed that both lines expressed all three of the isoforms of SAA: SAA1, SAA2, and SAA4.
These data suggest that some tumor cells are responsive to SAA and, in these cases, SAA may have a role in cancer progression that varies according to the cell type.
American Psychological Association (APA)
Knebel, Franciele Hinterholz& Albuquerque, Renata Chaves& Massaro, Renato Ramos& Maria-Engler, Silvya Stuchi& Campa, Ana. 2013. Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477281
Modern Language Association (MLA)
Knebel, Franciele Hinterholz…[et al.]. Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-477281
American Medical Association (AMA)
Knebel, Franciele Hinterholz& Albuquerque, Renata Chaves& Massaro, Renato Ramos& Maria-Engler, Silvya Stuchi& Campa, Ana. Dual Effect of Serum Amyloid A on the Invasiveness of Glioma Cells. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477281
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477281