Given Dimensions of Neoplastic Events as Aberrantly Operative Alternative Splicing
Author
Source
Pathology Research International
Issue
Vol. 2010, Issue 2010 (31 Dec. 2010), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-10-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The provision of dynamic splicing events constitutes the reflected nature of neoplasia that locally infiltrates and systemically spreads in terms of evolutionary attributes of the primary and various secondary pathways in malignant transformation.
The significant diversity in molecular characterization of the given tumor lesion would adaptively conform to dynamics of splicing as enhanced or silenced exons of the premessenger RNA molecule.
The proteins synthesized are in turn potential modifiers in further gene expression within such contexts as RNA:protein and RNA:DNA binding events.
The recognition of pathways of incremental scope would underline the development of lesions, such as tumors, as multiple alternative splicing phenomena primarily affecting molecular physicochemical identity.
It is within contexts of operative intervention and modification that the real identity of the malignant neoplastic process arises, within terms of reference of contextual splicing events.
Disrupted gene expression is thus a referential pathway in the modification of splicing that may prove constitutive or alternative, in first instance, but also aberrant as the lesion progresses locally and systemically.
American Psychological Association (APA)
Agius, Lawrence M.. 2009. Given Dimensions of Neoplastic Events as Aberrantly Operative Alternative Splicing. Pathology Research International،Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-477295
Modern Language Association (MLA)
Agius, Lawrence M.. Given Dimensions of Neoplastic Events as Aberrantly Operative Alternative Splicing. Pathology Research International No. 2010 (2010), pp.1-5.
https://search.emarefa.net/detail/BIM-477295
American Medical Association (AMA)
Agius, Lawrence M.. Given Dimensions of Neoplastic Events as Aberrantly Operative Alternative Splicing. Pathology Research International. 2009. Vol. 2010, no. 2010, pp.1-5.
https://search.emarefa.net/detail/BIM-477295
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477295