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Endoplasmic Reticulum Stress and Insulin Biosynthesis : A Review
Joint Authors
Kim, Mi-Kyung
Kim, Hye-Soon
Lee, In-Kyu
Park, Keun-Gyu
Source
Experimental Diabetes Research
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Insulin resistance and pancreatic beta cell dysfunction are major contributors to the pathogenesis of diabetes.
Various conditions play a role in the pathogenesis of pancreatic beta cell dysfunction and are correlated with endoplasmic reticulum (ER) stress.
Pancreatic beta cells are susceptible to ER stress.
Many studies have shown that increased ER stress induces pancreatic beta cell dysfunction and diabetes mellitus using genetic models of ER stress and by various stimuli.
There are many reports indicating that ER stress plays an important role in the impairment of insulin biosynthesis, suggesting that reduction of ER stress could be a therapeutic target for diabetes.
In this paper, we reviewed the relationship between ER stress and diabetes and how ER stress controls insulin biosynthesis.
American Psychological Association (APA)
Kim, Mi-Kyung& Kim, Hye-Soon& Lee, In-Kyu& Park, Keun-Gyu. 2012. Endoplasmic Reticulum Stress and Insulin Biosynthesis : A Review. Experimental Diabetes Research،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477318
Modern Language Association (MLA)
Kim, Mi-Kyung…[et al.]. Endoplasmic Reticulum Stress and Insulin Biosynthesis : A Review. Experimental Diabetes Research No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-477318
American Medical Association (AMA)
Kim, Mi-Kyung& Kim, Hye-Soon& Lee, In-Kyu& Park, Keun-Gyu. Endoplasmic Reticulum Stress and Insulin Biosynthesis : A Review. Experimental Diabetes Research. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477318