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Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation
Joint Authors
Erkhembaatar, Munkhsoyol
Hwang, Jin-Ki
Lee, Young-Rae
Gu, Dong Ryun
Kwon, Kang Beom
Kim, Min Seuk
Lee, Seoung Hoon
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-09-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Chrysanthemum zawadskii Herbich var.
latilobum Kitamura, known as “Gujulcho” in Korea, has been used in traditional medicine to treat various inflammatory diseases, including rheumatoid arthritis.
However, these effects have not been tested on osteoclasts, the bone resorbing cells that regulate bone metabolism.
Here, we investigated the effects of C.
zawadskii Herbich var.
latilobum Kitamura ethanol extract (CZE) on osteoclast differentiation induced by treatment with the receptor activator of NF-κB ligand (RANKL).
CZE inhibited osteoclast differentiation and formation in a dose-dependent manner.
The inhibitory effect of CZE on osteoclastogenesis was due to the suppression of ERK activation and the ablation of RANKL-stimulated Ca2+-oscillation via the inactivation of PLCγ2, followed by the inhibition of CREB activation.
These inhibitory effects of CZE resulted in a significant repression of c-Fos expression and a subsequent reduction of NFATc1, a key transcription factor for osteoclast differentiation, fusion, and activation in vitro and in vivo.
These results indicate that CZE negatively regulates osteoclast differentiation and may be a therapeutic candidate for the treatment of various bone diseases, such as postmenopausal osteoporosis, rheumatoid arthritis, and periodontitis.
American Psychological Association (APA)
Gu, Dong Ryun& Hwang, Jin-Ki& Erkhembaatar, Munkhsoyol& Kwon, Kang Beom& Kim, Min Seuk& Lee, Young-Rae…[et al.]. 2013. Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477322
Modern Language Association (MLA)
Gu, Dong Ryun…[et al.]. Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-477322
American Medical Association (AMA)
Gu, Dong Ryun& Hwang, Jin-Ki& Erkhembaatar, Munkhsoyol& Kwon, Kang Beom& Kim, Min Seuk& Lee, Young-Rae…[et al.]. Inhibitory Effect of Chrysanthemum zawadskii Herbich var. latilobum Kitamura Extract on RANKL-Induced Osteoclast Differentiation. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477322