The Effects of SIRT1 on Alzheimer's Disease Models
Author
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-3, 3 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-03
Country of Publication
Egypt
No. of Pages
3
Main Subjects
Abstract EN
Sirtuins are highly conserved NAD+-dependent enzymes that were shown to have beneficial effects against age-related diseases.
Aging is the major risk factor for all neurodegenerative disorders including Alzheimer’s Disease (AD).
Sirtuins have been widely studied in the context of AD using different mouse models.
In most of these studies, overexpression of SIRT1 has been shown to have protective effects against AD.
Therefore, designing therapeutics based on increasing SIRT1 activity might be important for investigating the ways of treatment for this disease.
This paper summarizes the recent research on the effect of SIRT1 in AD animal models and also the potential of SIRT1 being a therapeutical target for AD.
American Psychological Association (APA)
Donmez, Gizem. 2012. The Effects of SIRT1 on Alzheimer's Disease Models. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-477328
Modern Language Association (MLA)
Donmez, Gizem. The Effects of SIRT1 on Alzheimer's Disease Models. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-3.
https://search.emarefa.net/detail/BIM-477328
American Medical Association (AMA)
Donmez, Gizem. The Effects of SIRT1 on Alzheimer's Disease Models. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-3.
https://search.emarefa.net/detail/BIM-477328
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477328