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Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
Joint Authors
Päiväniemi, Outi E.
Maasilta, Paula K.
Salminen, Ulla-Stina
Vainikka, Tiina L. S.
Karhunen, PekkaJ.
Alho, Hanni S.
Source
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-26
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB).
Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation.
The autografts stayed patent.
In the allografts, proliferation of inflammatory cells (P<.0001) and fibroblasts (P=.02) resulted in occlusion of the bronchial lumens (P<.01).
Influx of CD4+ (P<.001) and CD8+ (P<.0001) cells demonstrated allograft immune response.
CRP positivity simultaneously increased in the bronchial walls (P<.01), in macrophages, myofibroblasts, and endothelial cells.
Local CRP was predictive of features characteristic of OB (R=0.456–0.879, P< .05−P<.0001).
Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05).
During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response.
American Psychological Association (APA)
Päiväniemi, Outi E.& Maasilta, Paula K.& Vainikka, Tiina L. S.& Alho, Hanni S.& Karhunen, PekkaJ.& Salminen, Ulla-Stina. 2009. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis. Mediators of Inflammation،Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-477384
Modern Language Association (MLA)
Päiväniemi, Outi E.…[et al.]. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis. Mediators of Inflammation No. 2009 (2009), pp.1-7.
https://search.emarefa.net/detail/BIM-477384
American Medical Association (AMA)
Päiväniemi, Outi E.& Maasilta, Paula K.& Vainikka, Tiina L. S.& Alho, Hanni S.& Karhunen, PekkaJ.& Salminen, Ulla-Stina. Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis. Mediators of Inflammation. 2009. Vol. 2009, no. 2009, pp.1-7.
https://search.emarefa.net/detail/BIM-477384
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477384