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Evidence of Extensive Homologous Recombination in the Core Genome of Rickettsia
Joint Authors
Bao, Qiyu
Yu, Tonghai
Wu, Jinyu
Zhao, Fangqing
Source
Comparative and Functional Genomics
Issue
Vol. 2009, Issue 2009 (31 Dec. 2009), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2009-05-25
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
The important role of homologous recombination has been extensively demonstrated to be fundamental for genetic variation in bacterial genomes.
In contrast to extracellular or facultative intracellular bacteria, obligate intracellular bacteria are considered to be less prone to recombination, especially for their core genomes.
In Rickettsia, only antigen-related genes were identified to have experienced homologous recombination.
In this study, we employed evolutionary genomic approaches to investigate the impact of recombination on the core genome of Rickettsia.
Phylogenetic network and phylogenetic compatibility matrix analyses are clearly consistent with the hypothesis that recombination has occurred frequently during Rickettsia evolution.
28% of Rickettsia core genes (194 out of 690) are found to present the evidence of recombination under four independent statistical methods.
Further functional classification shows that these recombination events occur across all functional categories, with a significant overrepresentation in the cell wall/membrane/envelope biogenesis, which may provide a molecular basis for the parasite adaptation to host immunity.
This evolutionary genomic analysis provides insight into the substantial role of recombination in the evolution of the intracellular pathogenic bacteria Rickettsia.
American Psychological Association (APA)
Wu, Jinyu& Yu, Tonghai& Bao, Qiyu& Zhao, Fangqing. 2009. Evidence of Extensive Homologous Recombination in the Core Genome of Rickettsia. Comparative and Functional Genomics،Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477386
Modern Language Association (MLA)
Wu, Jinyu…[et al.]. Evidence of Extensive Homologous Recombination in the Core Genome of Rickettsia. Comparative and Functional Genomics No. 2009 (2009), pp.1-5.
https://search.emarefa.net/detail/BIM-477386
American Medical Association (AMA)
Wu, Jinyu& Yu, Tonghai& Bao, Qiyu& Zhao, Fangqing. Evidence of Extensive Homologous Recombination in the Core Genome of Rickettsia. Comparative and Functional Genomics. 2009. Vol. 2009, no. 2009, pp.1-5.
https://search.emarefa.net/detail/BIM-477386
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477386