TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis
Joint Authors
Bogdanos, Dimitrios P.
Milkiewicz, Małgorzata
Smyk, Daniel S.
Kempinska-Podhorodecka, Agnieszka
Wunsch, Ewa
Milkiewicz, Piotr
Raszeja-Wyszomirska, Joanna
Source
Clinical and Developmental Immunology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-28
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Background.
Previous studies reported associations between specific alleles of non-HLA immunoregulatory genes and higher fatigue scores in patients with primary biliary cirrhosis (PBC).
Aim.
To study the relationship between variables of health-related quality of life (HRQoL) and single nucleotide polymorphisms of TRAF1-C5, a member of the tumor necrosis factor receptor family.
Patients and Methods.
TRAF1-C5 gene polymorphisms, rs2900180 and rs3761847, were analysed in 120 Caucasian PBCs.
The HRQoL was assessed with SF-36, PBC-40, and PBC-27 questionnaires.
Results.
We found a negative association between TT genotype of rs2900180 and SF-36’s domains vitality (P<0.05), mental health (P<0.05), and mental component summary score (P<0.05).
GG homozygotes of rs3761847 had lower vitality (P<0.05), mental health (P<0.05), mental component summary score (P<0.05) and impairment of social functioning (P<0.01).
Allelic analysis has shown that T allele of rs2900180 and G allele of rs3761847 related to SF-36’s vitality (P<0.05 and P<0.01), social functioning (P<0.05 and P<0.05), mental health (P<0.01 and P<0.05), and mental component summary score (P<0.01 and P<0.05), respectively.
Genotyping and allelic analysis did not reveal correlation with PBC-40 and PBC-27 domains.
Conclusion.
The association between rs2900180 and rs3761847 polymorphisms and HRQoL variables indicates that TRAF1 is involved in the induction of impaired QoL in PBC.
American Psychological Association (APA)
Raszeja-Wyszomirska, Joanna& Wunsch, Ewa& Kempinska-Podhorodecka, Agnieszka& Smyk, Daniel S.& Bogdanos, Dimitrios P.& Milkiewicz, Małgorzata…[et al.]. 2013. TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis. Clinical and Developmental Immunology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477422
Modern Language Association (MLA)
Raszeja-Wyszomirska, Joanna…[et al.]. TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis. Clinical and Developmental Immunology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-477422
American Medical Association (AMA)
Raszeja-Wyszomirska, Joanna& Wunsch, Ewa& Kempinska-Podhorodecka, Agnieszka& Smyk, Daniel S.& Bogdanos, Dimitrios P.& Milkiewicz, Małgorzata…[et al.]. TRAF1-C5 Affects Quality of Life in Patients with Primary Biliary Cirrhosis. Clinical and Developmental Immunology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477422
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477422