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Correlation of Endocrine Disrupting Chemicals Serum Levels and White Blood Cells Gene Expression of Nuclear Receptors in a Population of Infertile Women
Joint Authors
Fanello, Emiliano
Borghini, Francesca
Perra, Guido
Guerranti, Cristiana
Ciardo, Francesca
Tait, Sabrina
Soave, Ilaria
Stecca, Laura
Lo Monte, Giuseppe
Mantovani, Alberto
Bergamasco, Bruno
Marci, Roberto
Caserta, Donatella
Bordi, Giulia
Moscarini, Massimo
Focardi, Silvano Ettore
La Rocca, Cinzia
Source
International Journal of Endocrinology
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-04-21
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Significant evidence supports that many endocrine disrupting chemicals could affect female reproductive health.
Aim of this study was to compare the internal exposure to bisphenol A (BPA), perfluorooctane sulphonate (PFOS), perfluorooctanoic acid (PFOA), monoethylhexyl phthalate (MEHP), and di(2-ethylhexyl) phthalate (DEHP) in serum samples of 111 infertile women and 44 fertile women.
Levels of gene expression of nuclear receptors (ERα, ERβ, AR, AhR, PXR, and PPARγ) were also analyzed as biomarkers of effective dose.
The percentage of women with BPA concentrations above the limit of detection was significantly higher in infertile women than in controls.
No statistically significant difference was found with regard to PFOS, PFOA, MEHP and DEHP.
Infertile patients showed gene expression levels of ERα, ERβ, AR, and PXR significantly higher than controls.
In infertile women, a positive association was found between BPA and MEHP levels and ERα, ERβ, AR, AhR, and PXR expression.
PFOS concentration positively correlated with AR and PXR expression.
PFOA levels negatively correlated with AhR expression.
No correlation was found between DEHP levels and all evaluated nuclear receptors.
This study underlines the need to provide special attention to substances that are still widely present in the environment and to integrate exposure measurements with relevant indicators of biological effects.
American Psychological Association (APA)
Caserta, Donatella& Ciardo, Francesca& Bordi, Giulia& Guerranti, Cristiana& Fanello, Emiliano& Perra, Guido…[et al.]. 2013. Correlation of Endocrine Disrupting Chemicals Serum Levels and White Blood Cells Gene Expression of Nuclear Receptors in a Population of Infertile Women. International Journal of Endocrinology،Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477437
Modern Language Association (MLA)
Caserta, Donatella…[et al.]. Correlation of Endocrine Disrupting Chemicals Serum Levels and White Blood Cells Gene Expression of Nuclear Receptors in a Population of Infertile Women. International Journal of Endocrinology No. 2013 (2013), pp.1-7.
https://search.emarefa.net/detail/BIM-477437
American Medical Association (AMA)
Caserta, Donatella& Ciardo, Francesca& Bordi, Giulia& Guerranti, Cristiana& Fanello, Emiliano& Perra, Guido…[et al.]. Correlation of Endocrine Disrupting Chemicals Serum Levels and White Blood Cells Gene Expression of Nuclear Receptors in a Population of Infertile Women. International Journal of Endocrinology. 2013. Vol. 2013, no. 2013, pp.1-7.
https://search.emarefa.net/detail/BIM-477437
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477437