Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy
Joint Authors
Blasiak, Janusz
Romanowski, Marek
Chojnacki, Jan
Winczyk, Katarzyna
Chojnacki, Cezary
Source
Gastroenterology Research and Practice
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-30
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Cirrhotic patients exhibit disturbed melatonin homeostasis, which may lead to sleep disturbances, but an influence on the hepatic encephalopathy has not been elucidated.
Aim.
In the present study, the association of melatonin levels in serum and ascitic fluid and ammonia concentration related to the intensity of hepatic encephalopathy (HE) was investigated.
Material and Methods.
The study included 90 alcoholic patients with hepatic encephalopathy and 30 healthy volunteers (C).
Patients were divided in three groups according to 0–4 West-Haven Score: HE1 (n=28), HE2 (n=30), and HE3 (n=32).
Melatonin was measured by radioimmune assay.
Results.
In fasting patients with hepatic encephalopathy we noted higher melatonin serum levels [pg/mL] than in healthy subjects groups: C—11.3 ± 3.9, HE1 – 34.3 ± 12.2 (P<0.01), HE2—54.8 ± 23.9, and HE3—119.8 ± 96.4 (P<0.001).
No correlation between melatonin and ammonia levels was found.
Melatonin was detected in ascetic fluid in 24 patients of group HE2 and 27 patients of group HE2 of hepatic encephalopathy.
Conclusions.
Our results suggest that high blood levels of melatonin in cirrhotic liver patients may account for some of the clinical manifestations of hepatic encephalopathy, for example, daytime sleepiness, fatigue.
American Psychological Association (APA)
Chojnacki, Cezary& Romanowski, Marek& Winczyk, Katarzyna& Blasiak, Janusz& Chojnacki, Jan. 2012. Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477440
Modern Language Association (MLA)
Chojnacki, Cezary…[et al.]. Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-477440
American Medical Association (AMA)
Chojnacki, Cezary& Romanowski, Marek& Winczyk, Katarzyna& Blasiak, Janusz& Chojnacki, Jan. Melatonin Levels in Serum and Ascitic Fluid of Patients with Hepatic Encephalopathy. Gastroenterology Research and Practice. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-477440
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477440