Automated VOI Analysis in FDDNP PET Using Structural Warping : Validation through Classification of Alzheimer's Disease Patients
Joint Authors
Protas, Hillary
Barrio, Jorge R.
Kepe, Vladimir
Wilks, Moses Q.
Huang, Sung-Cheng
Wardak, Mirwais
Small, Gary W.
Source
International Journal of Alzheimer's Disease
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-01
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
We evaluate an automated approach to the cortical surface mapping (CSM) method of VOI analysis in PET.
Although CSM has been previously shown to be successful, the process can be long and tedious.
Here, we present an approach that removes these difficulties through the use of 3D image warping to a common space.
We test this automated method using studies of FDDNP PET in Alzheimer's disease and mild cognitive impairment.
For each subject, VOIs were created, through CSM, to extract regional PET data.
After warping to the common space, a single set of CSM-generated VOIs was used to extract PET data from all subjects.
The data extracted using a single set of VOIs outperformed the manual approach in classifying AD patients from MCIs and controls.
This suggests that this automated method can remove variance in measurements of PET data and can facilitate accurate, high-throughput image analysis.
American Psychological Association (APA)
Wilks, Moses Q.& Protas, Hillary& Wardak, Mirwais& Kepe, Vladimir& Small, Gary W.& Barrio, Jorge R.…[et al.]. 2012. Automated VOI Analysis in FDDNP PET Using Structural Warping : Validation through Classification of Alzheimer's Disease Patients. International Journal of Alzheimer's Disease،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-477470
Modern Language Association (MLA)
Wilks, Moses Q.…[et al.]. Automated VOI Analysis in FDDNP PET Using Structural Warping : Validation through Classification of Alzheimer's Disease Patients. International Journal of Alzheimer's Disease No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-477470
American Medical Association (AMA)
Wilks, Moses Q.& Protas, Hillary& Wardak, Mirwais& Kepe, Vladimir& Small, Gary W.& Barrio, Jorge R.…[et al.]. Automated VOI Analysis in FDDNP PET Using Structural Warping : Validation through Classification of Alzheimer's Disease Patients. International Journal of Alzheimer's Disease. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-477470
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477470