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Role of Dried Fruits of Carissa carandas as Anti-Inflammatory Agents and the Analysis of Phytochemical Constituents by GC-MS
Joint Authors
Anupama, N.
Madhumitha, G.
Rajesh, K. S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Inflammation plays an important role in various diseases with high prevalence within populations such as rheumatoid arthritis, ulcer, atherosclerosis, and asthma.
Many drugs are available in the market for inflammatory diseases.
They exhibit several unwanted side effects to humans.
Therefore, alternative treatments with safer compounds are needed.
Carissa carandas plant is used in traditional medicinal system for its various diseases curing property.
In the present study, we examined the anti-inflammatory effects of dried fruit methanol extract on carrageenan-induced hind paw edema in rats.
C.
carandas was defatted with petroleum ether, followed by methanol extraction.
The methanol extracts of the dried fruits of Carissa carandas were given orally to the experimental rats caused significant activity (P≤0.05) when compared with the control group.
The maximum inhibition of paw edema was found to be in Group V, that is, 76.12% with inhibition of paw volume in a dose-dependent manner.
The anti-inflammatory activity of the methanol extract of the dried fruits shows that the presence of potential constituents present in this extract may provide assistance in the drug discovery process.
The phytochemical compounds of the extract were screened by GC-MS analysis and it was found that 11 compounds are present in methanol extract of dried fruits of Carissa carandas.
American Psychological Association (APA)
Anupama, N.& Madhumitha, G.& Rajesh, K. S.. 2014. Role of Dried Fruits of Carissa carandas as Anti-Inflammatory Agents and the Analysis of Phytochemical Constituents by GC-MS. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477487
Modern Language Association (MLA)
Anupama, N.…[et al.]. Role of Dried Fruits of Carissa carandas as Anti-Inflammatory Agents and the Analysis of Phytochemical Constituents by GC-MS. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-477487
American Medical Association (AMA)
Anupama, N.& Madhumitha, G.& Rajesh, K. S.. Role of Dried Fruits of Carissa carandas as Anti-Inflammatory Agents and the Analysis of Phytochemical Constituents by GC-MS. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477487
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477487