The Melanocortin 3 Receptor : A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?
Joint Authors
Stewart, Laura K.
Phillips, Melody D.
Cheek, Dennis J.
Kirk, K. Michelle
Barbee, James J.
Henagan, Tara M.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-01-05
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Pharmacy, Health & Medical Sciences
Abstract EN
The purpose of this study was to determine whether resistance exercise training-induced reductions in inflammation are mediated via melanocortin 3 receptor expression in obese (BMI 32.7±3.7) women (65.6±2.8 yrs) randomized to either a control (N=11) or resistance training group (N=12).
The resistance trained group performed resistance training 3 days/week for 12 weeks.
Resting blood samples were collected before and after the training intervention in both resistance trained and control groups.
Resistance training upregulated melanocortin 3 receptor mRNA by 16-fold (P=.035) and decreased monocyte count, without changing leukocyte number, body composition, or body weight.
Resistance trained individuals exhibited increased sensitivity to inflammatory stimuli, whereas control individuals exhibited no change.
While there was no change in whole blood tumor necrosis factor alpha mRNA between the groups, whole blood interleukin 10 mRNA was higher in the resistance trained group following the intervention period.
In summary, it appears that resistance training may modulate melanocortin 3 receptor expression, providing a possible mechanism for the anti-inflammatory effects of exercise training.
American Psychological Association (APA)
Henagan, Tara M.& Phillips, Melody D.& Cheek, Dennis J.& Kirk, K. Michelle& Barbee, James J.& Stewart, Laura K.. 2011. The Melanocortin 3 Receptor : A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?. Journal of Aging Research،Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477511
Modern Language Association (MLA)
Henagan, Tara M.…[et al.]. The Melanocortin 3 Receptor : A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?. Journal of Aging Research No. 2011 (2011), pp.1-7.
https://search.emarefa.net/detail/BIM-477511
American Medical Association (AMA)
Henagan, Tara M.& Phillips, Melody D.& Cheek, Dennis J.& Kirk, K. Michelle& Barbee, James J.& Stewart, Laura K.. The Melanocortin 3 Receptor : A Novel Mediator of Exercise-Induced Inflammation Reduction in Postmenopausal Women?. Journal of Aging Research. 2011. Vol. 2011, no. 2011, pp.1-7.
https://search.emarefa.net/detail/BIM-477511
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477511