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Effects of the Hormone Kisspeptin on Reproductive Hormone Release in Humans
Joint Authors
Calley, Joanne L.
Dhillo, Waljit S.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-08-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Natural & Life Sciences (Multidisciplinary)
Biology
Abstract EN
The kisspeptins are a family of neuropeptides which act as upstream stimulators of gonadotrophin releasing hormone (GnRH) neurons.
Kisspeptin signalling is prerequisite to establishing the normal human reproductive phenotype; loss of function mutations in the KISS1 or KISS1R gene produces normosmic hypogonadotrophic hypogonadism in humans and mice, whilst increased activation of KISS1R causes precocious puberty.
Administration of exogenous kisspeptin to human subjects stimulates an acute gonadotrophin rise.
Serum kisspeptin levels also markedly increase during pregnancy.
The identification of kisspeptin has been one of the biggest discoveries in the field of reproductive endocrinology, since the isolation and sequencing of GnRH in 1977, and has generated a novel research avenue which has received much attention over the past decade.
This research has delineated many properties of the KISS1-KISS1R system, but there is still further work to do.
Understanding kisspeptin’s role throughout our reproductive lifetime should help us better understand—and therefore treat—disorders of reproductive function.
Promisingly, the current data supports the potential to develop kisspeptin based therapies.
As an outlook article this paper focusses predominantly on our groups recent investigations into the effects of kisspeptin administration to humans and the potential therapeutic role of kisspeptin.
American Psychological Association (APA)
Calley, Joanne L.& Dhillo, Waljit S.. 2014. Effects of the Hormone Kisspeptin on Reproductive Hormone Release in Humans. Advances in Biology،Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477517
Modern Language Association (MLA)
Calley, Joanne L.& Dhillo, Waljit S.. Effects of the Hormone Kisspeptin on Reproductive Hormone Release in Humans. Advances in Biology No. 2014 (2014), pp.1-10.
https://search.emarefa.net/detail/BIM-477517
American Medical Association (AMA)
Calley, Joanne L.& Dhillo, Waljit S.. Effects of the Hormone Kisspeptin on Reproductive Hormone Release in Humans. Advances in Biology. 2014. Vol. 2014, no. 2014, pp.1-10.
https://search.emarefa.net/detail/BIM-477517
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477517