Enzymatic Synthesis of Ampicillin : Nonlinear Modeling, Kinetics Estimation, and Adaptive Control
Joint Authors
Source
Journal of Biomedicine and Biotechnology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-28
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Nowadays, the use of advanced control strategies in biotechnology is quite low.
A main reason is the lack of quality of the data, and the fact that more sophisticated control strategies must be based on a model of the dynamics of bioprocesses.
The nonlinearity of the bioprocesses and the absence of cheap and reliable instrumentation require an enhanced modeling effort and identification strategies for the kinetics.
The present work approaches modeling and control strategies for the enzymatic synthesis of ampicillin that is carried out inside a fed-batch bioreactor.
First, a nonlinear dynamical model of this bioprocess is obtained by using a novel modeling procedure for biotechnology: the bond graph methodology.
Second, a high gain observer is designed for the estimation of the imprecisely known kinetics of the synthesis process.
Third, by combining an exact linearizing control law with the on-line estimation kinetics algorithm, a nonlinear adaptive control law is designed.
The case study discussed shows that a nonlinear feedback control strategy applied to the ampicillin synthesis bioprocess can cope with disturbances, noisy measurements, and parametric uncertainties.
Numerical simulations performed with MATLAB environment are included in order to test the behavior and the performances of the proposed estimation and control strategies.
American Psychological Association (APA)
Roman, Monica& Selişteanu, Dan. 2012. Enzymatic Synthesis of Ampicillin : Nonlinear Modeling, Kinetics Estimation, and Adaptive Control. Journal of Biomedicine and Biotechnology،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-477522
Modern Language Association (MLA)
Roman, Monica& Selişteanu, Dan. Enzymatic Synthesis of Ampicillin : Nonlinear Modeling, Kinetics Estimation, and Adaptive Control. Journal of Biomedicine and Biotechnology No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-477522
American Medical Association (AMA)
Roman, Monica& Selişteanu, Dan. Enzymatic Synthesis of Ampicillin : Nonlinear Modeling, Kinetics Estimation, and Adaptive Control. Journal of Biomedicine and Biotechnology. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-477522
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477522