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Pexophagy : The Selective Degradation of Peroxisomes
Joint Authors
Subramani, Suresh
Burnett, Sarah F.
Till, Andreas
Lakhani, Ronak
Source
International Journal of Cell Biology
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-18, 18 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-27
Country of Publication
Egypt
No. of Pages
18
Main Subjects
Abstract EN
Peroxisomes are single-membrane-bounded organelles present in the majority of eukaryotic cells.
Despite the existence of great diversity among different species, cell types, and under different environmental conditions, peroxisomes contain enzymes involved in β-oxidation of fatty acids and the generation, as well as detoxification, of hydrogen peroxide.
The exigency of all eukaryotic cells to quickly adapt to different environmental factors requires the ability to precisely and efficiently control peroxisome number and functionality.
Peroxisome homeostasis is achieved by the counterbalance between organelle biogenesis and degradation.
The selective degradation of superfluous or damaged peroxisomes is facilitated by several tightly regulated pathways.
The most prominent peroxisome degradation system uses components of the general autophagy core machinery and is therefore referred to as “pexophagy.” In this paper we focus on recent developments in pexophagy and provide an overview of current knowledge and future challenges in the field.
We compare different modes of pexophagy and mention shared and distinct features of pexophagy in yeast model systems, mammalian cells, and other organisms.
American Psychological Association (APA)
Till, Andreas& Lakhani, Ronak& Burnett, Sarah F.& Subramani, Suresh. 2012. Pexophagy : The Selective Degradation of Peroxisomes. International Journal of Cell Biology،Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-477530
Modern Language Association (MLA)
Till, Andreas…[et al.]. Pexophagy : The Selective Degradation of Peroxisomes. International Journal of Cell Biology No. 2012 (2012), pp.1-18.
https://search.emarefa.net/detail/BIM-477530
American Medical Association (AMA)
Till, Andreas& Lakhani, Ronak& Burnett, Sarah F.& Subramani, Suresh. Pexophagy : The Selective Degradation of Peroxisomes. International Journal of Cell Biology. 2012. Vol. 2012, no. 2012, pp.1-18.
https://search.emarefa.net/detail/BIM-477530
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477530