Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice
Joint Authors
Mohamed, Muhamad Idham
Abdul Razak, Hairil Rashmizal
Mohammad, Mohd Khairul Amran
Zakaria, Ainul Mardhiyah
Saad, Wan Mazlina Md.
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-04-29
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Watermelon is a natural product that contains high level of antioxidants and may prevent oxidative damage in tissues due to free radical generation following an exposure to ionizing radiation.
The present study aimed to investigate the radioprotective effects of watermelon (Citrullus lanatus (Thunb.) Matsum.
and Nakai) juice against oxidative damage induced by low dose X-ray exposure in mice.
Twelve adult male ICR mice were randomly divided into two groups consisting of radiation (Rx) and supplementation (Tx) groups.
Rx received filtered tap water, while Tx was supplemented with 50% (v/v) watermelon juice for 28 days ad libitum prior to total body irradiation by 100 μGy X-ray on day 29.
Brain, lung, and liver tissues were assessed for the levels of malondialdehyde (MDA), apurinic/apyrimidinic (AP) sites, glutathione (GSH), and superoxide dismutase (SOD) inhibition activities.
Results showed significant reduction of MDA levels and AP sites formation of Tx compared to Rx (P<0.05).
Mice supplemented with 50% watermelon juice restore the intracellular antioxidant activities by significantly increased SOD inhibition activities and GSH levels compared to Rx.
These findings may postulate that supplementation of 50% watermelon (Citrullus lanatus (Thunb.) Matsum.
and Nakai) juice could modulate oxidative damage induced by low dose X-ray exposure.
American Psychological Association (APA)
Mohammad, Mohd Khairul Amran& Mohamed, Muhamad Idham& Zakaria, Ainul Mardhiyah& Abdul Razak, Hairil Rashmizal& Saad, Wan Mazlina Md.. 2014. Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477544
Modern Language Association (MLA)
Mohammad, Mohd Khairul Amran…[et al.]. Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-477544
American Medical Association (AMA)
Mohammad, Mohd Khairul Amran& Mohamed, Muhamad Idham& Zakaria, Ainul Mardhiyah& Abdul Razak, Hairil Rashmizal& Saad, Wan Mazlina Md.. Watermelon (Citrullus lanatus (Thunb.) Matsum. and Nakai) Juice Modulates Oxidative Damage Induced by Low Dose X-Ray in Mice. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477544
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477544