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AT2 Receptor-Interacting Proteins ATIPs in the Brain
Joint Authors
Margottin-Goguet, Florence
le Rouzic, Erwann
Rodrigues-Ferreira, Sylvie
Pawlowski, Traci
Srivastava, Anand
Nahmias, Clara
Source
International Journal of Hypertension
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-01-23
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions.
Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2.
The present paper focuses on AT2 receptors, which have been reported to have neuroprotective effects on stroke, degenerative diseases, and cognitive functions.
Our group has identified a family of AT2 receptor interacting proteins (ATIPs) comprising three major members (ATIP1, ATIP3, and ATIP4) with different intracellular localization.
Of interest, all ATIP members are expressed in brain tissues and carry a conserved domain able to interact with the AT2 receptor intracellular tail, suggesting a role in AT2-mediated brain functions.
We summarize here current knowledge on the ATIP family of proteins, and we present new experimental evidence showing interaction defects between ATIP1 and two mutant forms of the AT2 receptor identified in cases of mental retardation.
These studies point to a functional role of the AT2/ATIP1 axis in cognition.
American Psychological Association (APA)
Rodrigues-Ferreira, Sylvie& le Rouzic, Erwann& Pawlowski, Traci& Srivastava, Anand& Margottin-Goguet, Florence& Nahmias, Clara. 2013. AT2 Receptor-Interacting Proteins ATIPs in the Brain. International Journal of Hypertension،Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477569
Modern Language Association (MLA)
Rodrigues-Ferreira, Sylvie…[et al.]. AT2 Receptor-Interacting Proteins ATIPs in the Brain. International Journal of Hypertension No. 2013 (2013), pp.1-6.
https://search.emarefa.net/detail/BIM-477569
American Medical Association (AMA)
Rodrigues-Ferreira, Sylvie& le Rouzic, Erwann& Pawlowski, Traci& Srivastava, Anand& Margottin-Goguet, Florence& Nahmias, Clara. AT2 Receptor-Interacting Proteins ATIPs in the Brain. International Journal of Hypertension. 2013. Vol. 2013, no. 2013, pp.1-6.
https://search.emarefa.net/detail/BIM-477569
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477569