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Molecular Markers for Breast Cancer : Prediction on Tumor Behavior
Joint Authors
Watanabe, Maria Angélica Ehara
Losi Guembarovski, Roberta
Ariza, Carolina Batista
Banin Hirata, Bruna Karina
Oda, Julie Massayo Maeda
Oliveira, Carlos Eduardo Coral de
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-01-28
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Breast cancer is one of the most common cancers with greater than 1,300,000 cases and 450,000 deaths each year worldwide.
The development of breast cancer involves a progression through intermediate stages until the invasive carcinoma and finally into metastatic disease.
Given the variability in clinical progression, the identification of markers that could predict the tumor behavior is particularly important in breast cancer.
The determination of tumor markers is a useful tool for clinical management in cancer patients, assisting in diagnostic, staging, evaluation of therapeutic response, detection of recurrence and metastasis, and development of new treatment modalities.
In this context, this review aims to discuss the main tumor markers in breast carcinogenesis.
The most well-established breast molecular markers with prognostic and/or therapeutic value like hormone receptors, HER-2 oncogene, Ki-67, and p53 proteins, and the genes for hereditary breast cancer will be presented.
Furthermore, this review shows the new molecular targets in breast cancer: CXCR4, caveolin, miRNA, and FOXP3, as promising candidates for future development of effective and targeted therapies, also with lower toxicity.
American Psychological Association (APA)
Banin Hirata, Bruna Karina& Oda, Julie Massayo Maeda& Losi Guembarovski, Roberta& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Watanabe, Maria Angélica Ehara. 2014. Molecular Markers for Breast Cancer : Prediction on Tumor Behavior. Disease Markers،Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-477577
Modern Language Association (MLA)
Banin Hirata, Bruna Karina…[et al.]. Molecular Markers for Breast Cancer : Prediction on Tumor Behavior. Disease Markers No. 2014 (2014), pp.1-12.
https://search.emarefa.net/detail/BIM-477577
American Medical Association (AMA)
Banin Hirata, Bruna Karina& Oda, Julie Massayo Maeda& Losi Guembarovski, Roberta& Ariza, Carolina Batista& Oliveira, Carlos Eduardo Coral de& Watanabe, Maria Angélica Ehara. Molecular Markers for Breast Cancer : Prediction on Tumor Behavior. Disease Markers. 2014. Vol. 2014, no. 2014, pp.1-12.
https://search.emarefa.net/detail/BIM-477577
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477577