![](/images/graphics-bg.png)
Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma
Joint Authors
Pećanić, Sanja
Aralica, Merica
Štifter, Sanja
Nemet, Damir
Valković, Toni
Lučin, Ksenija
Jonjić, Nives
Seili-Bekafigo, Irena
Duletić-Načinović, Antica
Babarović, Emina
Source
Issue
Vol. 2014, Issue 2014 (31 Dec. 2014), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2014-06-04
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The aim of this pilot study was to determine the plasma levels of osteopontin (OPN) and vascular endothelial growth factor (VEGF) and find possible association between them and main clinical features and parameters of tumor burden in patient with multiple myeloma (MM).
Plasma levels of OPN and VEGF were determined in 44 newly diagnosed MM patients and 24 healthy persons by ELISA method.
These values were compared with the presence of anemia, renal dysfunction, and bone lesions as myeloma related clinical manifestations and with serum beta-2 microglobulin and Durie-Salmon clinical stage as prognosticators related to tumor mass.
The value of OPN was significantly higher in MM patients with evident bone lesions (P=0.03) and there was also a positive correlation with serum beta-2 microglobulin (r=0.366; P=0.04).
Furthermore, patients with lower Durie-Salmon stage had significantly lower OPN and VEGF levels (P=0.05; P=0.04, resp.).
Our preliminary results found positive association between plasma level of OPN, tumor burden, and bone destruction.
Further analysis should provide information about the possible use of OPN as useful clinical biomarker for monitoring bone disease and tumor mass, as well as a prognostic factor, or a possible target for pharmacological intervention.
American Psychological Association (APA)
Valković, Toni& Babarović, Emina& Lučin, Ksenija& Štifter, Sanja& Aralica, Merica& Pećanić, Sanja…[et al.]. 2014. Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma. BioMed Research International،Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477579
Modern Language Association (MLA)
Valković, Toni…[et al.]. Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma. BioMed Research International No. 2014 (2014), pp.1-6.
https://search.emarefa.net/detail/BIM-477579
American Medical Association (AMA)
Valković, Toni& Babarović, Emina& Lučin, Ksenija& Štifter, Sanja& Aralica, Merica& Pećanić, Sanja…[et al.]. Plasma Levels of Osteopontin and Vascular Endothelial Growth Factor in Association with Clinical Features and Parameters of Tumor Burden in Patients with Multiple Myeloma. BioMed Research International. 2014. Vol. 2014, no. 2014, pp.1-6.
https://search.emarefa.net/detail/BIM-477579
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477579