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Role of Cox-2 in Vascular Inflammation : An Experimental Model of Metabolic Syndrome
Joint Authors
Lembo, Carina
Miatello, Roberto Miguel
Renna, Nicolas Federico
Diez, Emiliano R.
Source
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-02-14
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The objective of this work was to demonstrate the role of COX-2 enzyme at the vascular in experimental model of metabolic syndrome.
SHR male WKY rats were employed; they were distributed in 8 groups (n=8 each): control (W); W + L: WKY rats receiving 20 mg/kg of lumiracoxib by intraesophageal administration; SHR; SHR + L: SHR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Rats (FFR): WKY rats receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; FFR + L: FFR + 20 mg/kg of lumiracoxib by intraesophageal administration; Fructose-Fed Hypertensive Rats (FFHR): SHR receiving 10% (w/v) fructose solution in drinking water during all 12 weeks; and FFHR + L: FFHR + 20 mg/kg of lumiracoxib by intraesophageal administration.
Metabolic variables, blood pressure, morphometric variables, and oxidative stress variables were evaluated; also MMP-2 and MMP-9 (collagenases), VCAM-1, and NF-κB by Westernblot or IFI were evaluated.
FFHR presented all variables of metabolic syndrome; there was also an increase in oxidative stress variables; vascular remodeling and left ventricular hypertrophy were evidenced along with a significant increase in the expression of the mentioned proinflammatory molecules and increased activity and expression of collagenase.
Lumiracoxib was able to reverse vascular remodeling changes and inflammation, demonstrating the involvement of COX-2 in the pathophysiology of vascular remodeling in this experimental model.
American Psychological Association (APA)
Renna, Nicolas Federico& Diez, Emiliano R.& Lembo, Carina& Miatello, Roberto Miguel. 2013. Role of Cox-2 in Vascular Inflammation : An Experimental Model of Metabolic Syndrome. Mediators of Inflammation،Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477593
Modern Language Association (MLA)
Renna, Nicolas Federico…[et al.]. Role of Cox-2 in Vascular Inflammation : An Experimental Model of Metabolic Syndrome. Mediators of Inflammation No. 2013 (2013), pp.1-10.
https://search.emarefa.net/detail/BIM-477593
American Medical Association (AMA)
Renna, Nicolas Federico& Diez, Emiliano R.& Lembo, Carina& Miatello, Roberto Miguel. Role of Cox-2 in Vascular Inflammation : An Experimental Model of Metabolic Syndrome. Mediators of Inflammation. 2013. Vol. 2013, no. 2013, pp.1-10.
https://search.emarefa.net/detail/BIM-477593
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477593