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Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice
Joint Authors
Sheu, Fuu
Hsu, Hsien-Yeh
Ma, Li-Juan
Kuan, Yen-Chou
Tsao, Shu-Ming
Lin, Tung-Yi
Hsu, Jason
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2013, Issue 2013 (31 Dec. 2013), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2013-06-24
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
LZ-8, an immunomodulatory protein isolated from Ganoderma lucidum (also known as Ling-Zhi or Reishi), has been shown to promote cell proliferation and IL-2 production in T cells.
In this study, we show that LZ-8 induces the expansion of both murine and human CD4+ T cells into FOXP3+ regulatory T (Treg) cells.
LZ-8 treatment was found to stimulate a 4-fold and a 10-fold expansion in the Treg populations of murine and human primary CD4+ T cells, respectively.
In addition, the expression of CTLA-4 and IL-10 was induced in LZ-8-treated CD4+ T cells.
Using neutralizing antibodies and gene-deficient T-cell lines, we also found that LZ-8 promotes Treg expansion through a CD45-mediated signaling pathway and that the CD18-dependent induction of IL-2 was involved in Treg formation and IL-10 production.
The suppressive activity of LZ-8 was confirmed using a murine model of DSS-induced colitis; the disease was alleviated by the adoptive transfer of LZ-8-treated CD4+ T cells.
In conclusion, a new regulatory function for LZ-8 was identified, and the molecular mechanisms underlying this function were elucidated.
American Psychological Association (APA)
Hsu, Hsien-Yeh& Kuan, Yen-Chou& Lin, Tung-Yi& Tsao, Shu-Ming& Hsu, Jason& Ma, Li-Juan…[et al.]. 2013. Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477613
Modern Language Association (MLA)
Hsu, Hsien-Yeh…[et al.]. Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine No. 2013 (2013), pp.1-11.
https://search.emarefa.net/detail/BIM-477613
American Medical Association (AMA)
Hsu, Hsien-Yeh& Kuan, Yen-Chou& Lin, Tung-Yi& Tsao, Shu-Ming& Hsu, Jason& Ma, Li-Juan…[et al.]. Reishi Protein LZ-8 Induces FOXP3+ Treg Expansion via a CD45-Dependent Signaling Pathway and Alleviates Acute Intestinal Inflammation in Mice. Evidence-Based Complementary and Alternative Medicine. 2013. Vol. 2013, no. 2013, pp.1-11.
https://search.emarefa.net/detail/BIM-477613
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-477613